Non-nucleoside reverse transcriptase inhibitors (NNRTIs): A brief overview of clinically approved drugs and combination regimens

M Vanangamudi, S Kurup, V Namasivayam - Current opinion in …, 2020 - Elsevier
The non-nucleoside reverse transcriptase inhibitors (NNRTIs) are allosteric inhibitors of HIV-
1 reverse transcriptase and are classified into generations depending on their discovery and …

Non-nucleoside reverse transcriptase inhibitors: the NNRTI boom

OS Pedersen, EB Pedersen - Antiviral Chemistry and …, 1999 - journals.sagepub.com
Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are promising drugs for the
treatment of HIV when used in combination with other anti-HIV drugs such as nucleoside …

Novel HIV-1 non-nucleoside reverse transcriptase inhibitors: a patent review (2005–2010)

P Zhan, X Liu - Expert opinion on therapeutic patents, 2011 - Taylor & Francis
Introduction: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) form the backbone of
antiretroviral treatment for many HIV-infected individuals. The unique antiviral activity, high …

Current and emerging non-nucleoside reverse transcriptase inhibitors (NNRTIs) for HIV-1 treatment

Y Wang, E De Clercq, G Li - Expert opinion on drug metabolism & …, 2019 - Taylor & Francis
Introduction: Non-nucleoside reverse transcriptase inhibitors (NNRTIs) are essential
components of highly active antiretroviral therapy against HIV-1 infections. Here, we provide …

Non-nucleoside HIV-1 reverse transcriptase (RT) inhibitors: past, present, and future perspectives

G Campiani, A Ramunno, G Maga… - Current …, 2002 - ingentaconnect.com
Along with nucleoside reverse transcriptase inhibitors (NRTIs) and protease inhibitors (PIs),
nonnucleoside reverse transcriptase inhibitors (NNRTIs) have gained a definitive and …

Twenty years of HIV-1 non-nucleoside reverse transcriptase inhibitors: time to reevaluate their toxicity

A Blas-Garcia, JV Esplugues… - Current medicinal …, 2011 - ingentaconnect.com
Twenty years of effective clinical application have consolidated non-nucleoside reverse
transcriptase inhibitors (NNRTI) as essential components of the Highly Active Antiretroviral …

Practical considerations for developing nucleoside reverse transcriptase inhibitors

SJ Hurwitz, RF Schinazi - Drug Discovery Today: Technologies, 2012 - Elsevier
Nucleoside reverse transcriptase inhibitors (NRTI) remain a cornerstone of current
antiretroviral regimens in combinations usually with a nonnucleoside reverse transcriptase …

Challenges for the clinical development of new nucleoside reverse transcriptase inhibitors for HIV infection

MA Wainberg, JPC Sawyer, JSG Montaner… - Antiviral …, 2005 - journals.sagepub.com
There is a need for new antiretroviral drugs with activity against HIV isolates resistant to
currently available agents and improved short and long-term tolerability profiles. Clinical trial …

Developing novel nonnucleoside HIV-1 reverse transcriptase inhibitors: beyond the butterfly

A Basavapathruni, KS Anderson - Current pharmaceutical …, 2006 - ingentaconnect.com
To date three nonnucleoside reverse transcriptase inhibitors (NNRTIs) have been approved
by the US Food and Drug Administration for the treatment of human immunodeficiency virus …

Non-nucleoside reverse transcriptase inhibitors

V Joly, P Yeni - Annales de medecine interne, 2000 - europepmc.org
The non-nucleoside reverse transcriptase inhibitors (NNRTIs) directly inhibit the HIV-1
reverse transcriptase (RT) by binding in a reversible and non-competitive manner to the …