T cells can acquire a broad spectrum of differentiation states following activation. At the
extreme ends of this continuum are short-lived cells equipped with effector machinery and …

Memory and effector T cells have the potential to counteract cancer progression, but often
fail to control the disease, essentially because of three main stumbling blocks. First, clonal …

The generation and maintenance of CD 8+ T cell memory is crucial to long‐term host
survival, yet the basic tenets of CD 8+ T cell immunity are still being established. Recent …

Prolonged exposure of CD8+ T cells to their cognate antigen can result in exhaustion of
effector functions enabling the persistence of infected or transformed cells. Recent advances …

T cells mediate anti-tumor immune responses and are the key target of immune checkpoint
therapy, but they can also promote immune tolerance. A clear understanding of the specific …

The goal of successful anti-tumoural immunity is the development of long-term protective
immunity to prevent relapse. Infiltration of tumours with CD8+ T cells with a resident memory …

A paradigm shift in the understanding of the exhausted CD8+ T cell (Tex) lineage is
underway. Originally thought to be a uniform population that progressively loses effector …

Stem cells are defined by the ability to self-renew and to generate differentiated progeny,
qualities that are maintained by evolutionarily conserved pathways that can lead to cancer …

Long-lived memory CD8+ T cells play important roles in tumor immunity. Studies over the
past two decades have identified four subsets of memory CD8+ T cells-central, effector, stem …

Tumor-specific CD8+ T cells are exposed to persistent antigenic stimulation which induces a
dysfunctional state called “exhaustion.” Though functioning to limit damage caused by …