Dysplastic naevi (DN) are a known risk factor for malignant melanoma. Their occurrence is
closely connected with the degree of skin pigmentation. People with a light complexion are …

Melanin synthesis is an oxygen‐dependent process that acts as a potential source of
reactive oxygen species (ROS) inside pigment‐forming cells. The synthesis of the lighter …

Certain aspects of current progress in melanin biology and its possible clinical relevances
are reviewed with emphasis on some of our recent research activities. The important aspects …

The degree and type of melanogenesis, ie, either eumelanin of pheomelanin, has been
shown to be a reliable marker for the differentiation of the melanocyte. If exposed to UV light …

Melanins are ubiquitous catecholic pigments, formed in organelles called melanosomes
within melanocytes, the function of which is to protect skin against harmful effects of UV …

Melanoma is the most aggressive skin cancer, with a growing number of incidents
worldwide and with no effective cure in a metastatic stage so far. There are several …

Background The risk of malignant melanoma associated with histologically dysplastic naevi
(HDN) has not been defined. While clinically atypical naevi appear to confer an independent …

Patients with familial atypical multiple mole and melanoma (FAMMM)[so-called familial
dysplastic naevus syndrome (FDNS)] have a high risk for the development of malignant …

Considering that stimulation of melanogenesis may lead to alterations of cellular responses,
besides melanin production, our main goal was to study the cellular effects of …

Melanocytes are producing melanin after UV irradiation as a defense mechanism. However,
UV-induced damage is involved in melanoma initiation, depending on skin phototype …