Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease
Glia have been implicated in Alzheimer's disease (AD) pathogenesis. Variants of the
microglia receptor triggering receptor expressed on myeloid cells 2 (TREM2) increase AD …
microglia receptor triggering receptor expressed on myeloid cells 2 (TREM2) increase AD …
Identification of senescent, TREM2-expressing microglia in aging and Alzheimer's disease model mouse brain
N Rachmian, S Medina, U Cherqui, H Akiva… - Nature …, 2024 - nature.com
Alzheimer's disease (AD) and dementia in general are age-related diseases with multiple
contributing factors, including brain inflammation. Microglia, and specifically those …
contributing factors, including brain inflammation. Microglia, and specifically those …
[HTML][HTML] TREM2-independent oligodendrocyte, astrocyte, and T cell responses to tau and amyloid pathology in mouse models of Alzheimer disease
SH Lee, MG Rezzonico, BA Friedman, MH Huntley… - Cell Reports, 2021 - cell.com
Non-neuronal responses in neurodegenerative disease have received increasing attention
as important contributors to disease pathogenesis and progression. Here we utilize single …
as important contributors to disease pathogenesis and progression. Here we utilize single …
[HTML][HTML] Gene expression and functional deficits underlie TREM2-knockout microglia responses in human models of Alzheimer's disease
The discovery of TREM2 as a myeloid-specific Alzheimer's disease (AD) risk gene has
accelerated research into the role of microglia in AD. While TREM2 mouse models have …
accelerated research into the role of microglia in AD. While TREM2 mouse models have …
[HTML][HTML] TREM2-activating antibodies abrogate the negative pleiotropic effects of the Alzheimer's disease variant Trem2R47H on murine myeloid cell function
Q Cheng, J Danao, S Talreja, P Wen, J Yin… - Journal of Biological …, 2018 - ASBMB
Triggering receptor expressed on myeloid cells 2 (TREM2) is an orphan immune receptor
expressed on cells of myeloid lineage such as macrophages and microglia. The rare variant …
expressed on cells of myeloid lineage such as macrophages and microglia. The rare variant …
TREM2 function in Alzheimer's disease and neurodegeneration
JD Ulrich, DM Holtzman - ACS chemical neuroscience, 2016 - ACS Publications
Alzheimer's disease (AD), the most common cause of dementia in the elderly, is a complex
neurodegenerative disease marked by the appearance of amyloid-β (Aβ) plaques and …
neurodegenerative disease marked by the appearance of amyloid-β (Aβ) plaques and …
[HTML][HTML] The Trem2 R47H Alzheimer's risk variant impairs splicing and reduces Trem2 mRNA and protein in mice but not in humans
Abstract Background The R47H variant of the Triggering Receptor Expressed on Myeloid
cells 2 (TREM2) significantly increases the risk for late onset Alzheimer's disease. Mouse …
cells 2 (TREM2) significantly increases the risk for late onset Alzheimer's disease. Mouse …
TREM2 in Alzheimer's disease
T Jiang, JT Yu, XC Zhu, L Tan - Molecular neurobiology, 2013 - Springer
Recent works have demonstrated a rare functional variant (R47H) in triggering receptor
expressed on myeloid cells (TREM) 2 gene, encoding TREM2 protein, increase …
expressed on myeloid cells (TREM) 2 gene, encoding TREM2 protein, increase …
TREM2 deficiency eliminates TREM2+ inflammatory macrophages and ameliorates pathology in Alzheimer's disease mouse models
TR Jay, CM Miller, PJ Cheng, LC Graham… - Journal of Experimental …, 2015 - rupress.org
Variants in triggering receptor expressed on myeloid cells 2 (TREM2) confer high risk for
Alzheimer's disease (AD) and other neurodegenerative diseases. However, the cell types …
Alzheimer's disease (AD) and other neurodegenerative diseases. However, the cell types …
[HTML][HTML] TREM2 splice isoforms generate soluble TREM2 species that disrupt long-term potentiation
Background TREM2 is a transmembrane receptor expressed by myeloid cells and acts to
regulate their immune response. TREM2 governs the response of microglia to amyloid and …
regulate their immune response. TREM2 governs the response of microglia to amyloid and …