Background Evidence about the optimal time of day at which to administer statins is lacking.
Objective The objective of this study is to synthesize evidence about effects of morning vs …

The current limited evidence suggests that short-acting statins should be given in the
evening whereas long-acting statins could be given at any time of the day with allowing …

Objective: To determine the best time to administer statins for optimal lowering of low-density
lipoprotein cholesterol (LDL-C) by reviewing the clinical evidence evaluating the …

Objectives: To compare lipid-lowering efficacy and high sensitive C-reactive protein
(hsCRP) level between morning and evening simvastatin administration in hyperlipidemia …

Background Flexibility in the recommended dosing time for a statin may improve patient
compliance. Objective This study was designed to compare the efficacy and tolerability of …

BACKGROUND: Statins are the treatment of choice for lowering LDL-C levels and reducing
cardiovascular events. They have a remarkable safety profile, although some patients do not …

Purpose We conducted a meta-analysis of randomized controlled trials (RCTs) and quasi-
RCTs to synthesize evidence about the efficacy and safety of alternate-day vs daily dosing of …

Purpose Evening administration of the conventional immediate-release (IR) formulation of
simvastatin is recommended because of its short half-life (1.9 hours). In a healthy …

Background Elevated levels of total cholesterol and low‐density lipoprotein play an
important role in the development of atheromas and, therefore, in cardiovascular diseases …

Background: Flexibility in the time of administration of statin therapy is likely to improve
patient compliance. This study compared the efficacy and tolerability of morning and …