Modulation of glial activation by astrocyte-derived protein S100B: differential responses of astrocyte and microglial cultures

TV Petrova, J Hu, LJ Van Eldik - Brain research, 2000 - Elsevier
The astrocyte-derived protein S100B stimulates production of inducible nitric oxide synthase
and nitric oxide (NO) in astrocytes [Hu et al., 1996, J. Biol. Chem. 271: 2543], but its effect on …

S100β stimulates inducible nitric oxide synthase activity and mRNA levels in rat cortical astrocytes

J Hu, F Castets, JL Guevara, LJ Van Eldik - Journal of Biological Chemistry, 1996 - ASBMB
The glia-derived, neurotrophic protein S100β has been implicated in development and
maintenance of the nervous system. However, S100β has also been postulated to play a …

S100B proteins that lack one or both cysteine residues can induce inflammatory responses in astrocytes and microglia

T Koppal, AGM Lam, L Guo, LJ Van Eldik - Neurochemistry international, 2001 - Elsevier
The astrocytic protein S100B stimulates neurite outgrowth and neuronal survival during CNS
development. S100B can also stimulate glial activation, leading to induction of pro …

S100β induces neuronal cell death through nitric oxide release from astrocytes

J Hu, A Ferreira, LJ Van Eldik - Journal of neurochemistry, 1997 - Wiley Online Library
The glial‐derived neurotrophic protein S100β has been implicated in the development and
maintenance of the nervous system. S100β has also been postulated to play a role in …

S100B expression in and effects on microglia

C Adami, G Sorci, E Blasi, AL Agneletti, F Bistoni… - Glia, 2001 - Wiley Online Library
We evaluated the intracellular and extracellular biological role of S100B protein with respect
to microglia. S100B, which belongs to the multigenic family of Ca2+‐binding proteins, is …

Developmental changes in S100B content in brain tissue, cerebrospinal fluid, and astrocyte cultures of rats

F Tramontina, S Conte, D Gonçalves… - Cellular and Molecular …, 2002 - Springer
We investigated the content of S100B protein by ELISA in three brain regions (hippocampus,
cerebral cortex, and cerebellum) and in cerebrospinal fluid of rats during postnatal …

S100B is expressed in, and released from, OLN-93 oligodendrocytes: influence of serum and glucose deprivation

J Steiner, HG Bernstein, B Bogerts, T Gos… - Neuroscience, 2008 - Elsevier
S100B (member of a family of proteins that are 100% soluble in ammonium sulfate at neutral
pH) has been widely used as astrocyte marker in animal models and in human brain …

S100B modulates growth factors and costimulatory molecules expression in cultured human astrocytes

C Reali, R Pillai, F Saba, S Cabras, F Michetti… - Journal of …, 2012 - Elsevier
S100B is a Ca2+-binding protein expressed in the nervous system. Increased levels of
S100B in the extracellular space have been detected in several neurological disorders. We …

S100B: astrocyte specific protein

N Tateishi, T Shimoda, N Yada… - … Japanese Journal of …, 2006 - europepmc.org
The S100B is a Ca2+ binding proteins of EF-hand type and is produced primarily by
astrocytes in the central nervous system. This protein has been implicated in the Ca2+ …

S100β induces apoptotic cell death in cultured astrocytes via a nitric oxide-dependent pathway

J Hu, LJ Van Eldik - Biochimica et Biophysica Acta (BBA)-Molecular Cell …, 1996 - Elsevier
S100β is a calcium binding protein expressed primarily by astrocytes in the brain. In
initiating studies of the toxic signalling pathways activated by high concentrations of S100β …