[HTML][HTML] Intermethod comparability analyses of gepotidacin antimicrobial susceptibility tests using a large collection of globally collected Escherichia coli and …
SJR Arends, D Butler, N Scangarella-Oman… - … and Infectious Disease, 2024 - Elsevier
Gepotidacin (GSK2140944) is a novel, bactericidal, first in class triazaacenaphthylene
bacterial type II topoisomerase inhibitor in development for the treatment of uncomplicated …
bacterial type II topoisomerase inhibitor in development for the treatment of uncomplicated …
Comparison of minimum inhibitory concentration results for gepotidacin obtained using agar dilution and broth microdilution methods
SJR Arends, MA Canino, R Mendes… - … and Infectious Disease, 2020 - Elsevier
Gepotidacin (GSK2140944) is a first in class, novel triazaacenaphthylene bacterial type II
topoisomerase inhibitor in Phase 3 clinical development for the treatment of gonorrhea and …
topoisomerase inhibitor in Phase 3 clinical development for the treatment of gonorrhea and …
Analysis of MIC and disk diffusion testing variables for gepotidacin and comparator agents against select bacterial pathogens
LM Koeth, JM DiFranco-Fisher… - Journal of Clinical …, 2017 - Am Soc Microbiol
This study was conducted to determine the effect of testing parameters on the in vitro activity
of gepotidacin, a new triazaacenaphthylene antibacterial agent for the treatment of …
of gepotidacin, a new triazaacenaphthylene antibacterial agent for the treatment of …
Multicenter investigation of gepotidacin (GSK2140944) agar dilution quality control determinations for Neisseria gonorrhoeae ATCC 49226
RN Jones, KA Fedler… - Antimicrobial agents …, 2016 - Am Soc Microbiol
Gepotidacin, a novel triazaacenaphthylene antibacterial agent, is the first in a new class of
type IIA topoisomerase inhibitors with activity against many biothreat and conventional …
type IIA topoisomerase inhibitors with activity against many biothreat and conventional …
Gepotidacin (GSK2140944) In Vitro Activity against Gram-Positive and Gram-Negative Bacteria
RK Flamm, DJ Farrell, PR Rhomberg… - Antimicrobial agents …, 2017 - Am Soc Microbiol
Gepotidacin is a first-in-class, novel triazaacenaphthylene antibiotic that inhibits bacterial
DNA replication and has in vitro activity against susceptible and drug-resistant pathogens …
DNA replication and has in vitro activity against susceptible and drug-resistant pathogens …
In Vitro Activity and Microbiological Efficacy of Gepotidacin from a Phase 2, Randomized, Multicenter, Dose-Ranging Study in Patients with Acute Bacterial Skin and …
NE Scangarella-Oman, KA Ingraham… - Antimicrobial Agents …, 2020 - Am Soc Microbiol
ABSTRACT A phase 2 study of gepotidacin demonstrated the safety and efficacy of 3
gepotidacin doses (750 mg every 12 h [q12h], 1,000 mg q12h, and 1,000 mg every 8 h …
gepotidacin doses (750 mg every 12 h [q12h], 1,000 mg q12h, and 1,000 mg every 8 h …
[HTML][HTML] Analysis of the effect of urine on the in vitro activity of gepotidacin and levofloxacin against Escherichia coli, Staphylococcus epidermidis, and Staphylococcus …
LM Koeth, JM DiFranco-Fisher… - … and Infectious Disease, 2023 - Elsevier
Gepotidacin is a novel agent in development for treatment of gonorrhea and uncomplicated
urinary tract infection. This study determined the effect of urine on the in vitro activity of …
urinary tract infection. This study determined the effect of urine on the in vitro activity of …
Efficacy of Human Exposures of Gepotidacin (GSK2140944) against Escherichia coli in a Rat Pyelonephritis Model
JL Hoover, CM Singley, P Elefante… - Antimicrobial Agents …, 2019 - Am Soc Microbiol
Gepotidacin is a first-in-class triazaacenaphthylene antibacterial that inhibits bacterial type II
topoisomerases and has in vitro activity against a range of bacterial pathogens, including …
topoisomerases and has in vitro activity against a range of bacterial pathogens, including …
Pharmacokinetic-pharmacodynamic evaluation of gepotidacin against Gram-positive organisms using data from murine infection models
CC Bulik, ÓO Okusanya, EA Lakota… - Antimicrobial Agents …, 2017 - Am Soc Microbiol
Gepotidacin (formerly called GSK2140944) is a novel triazaacenaphthylene bacterial
topoisomerase inhibitor with in vitro activity against conventional and biothreat pathogens …
topoisomerase inhibitor with in vitro activity against conventional and biothreat pathogens …
In Vitro Activity of Gepotidacin (GSK2140944) against Neisseria gonorrhoeae
DJ Farrell, HS Sader, PR Rhomberg… - Antimicrobial agents …, 2017 - Am Soc Microbiol
Gepotidacin (formerly GSK2140944) is a novel, first-in-class, triazaacenaphthylene
antibacterial that inhibits bacterial DNA gyrase and topoisomerase IV via a unique …
antibacterial that inhibits bacterial DNA gyrase and topoisomerase IV via a unique …
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