Machine learning and single-cell RNA sequencing reveal relationship between intratumor CD8+ T cells and uveal melanoma metastasis

S Chen, Z Tang, Q Wan, W Huang, X Li, X Huang… - Cancer Cell …, 2024 - Springer
Purpose Uveal melanoma (UM) is adults' most common primary intraocular malignant tumor.
It has been observed that 40% of patients experience distant metastasis during subsequent …

Identification of co-expressed gene networks promoting CD8+ T cell infiltration and having prognostic value in uveal melanoma

C Zhang, J Xiao, L Fa, F Jiang, H Jiang, L Zhou… - BMC …, 2023 - Springer
Current immunotherapies are unsatisfactory against uveal melanoma (UM); however,
elevated CD8+ T cell infiltration level indicates poor prognosis in UM. Here, we aimed to …

Construction of a promising tumor-infiltrating CD8+ T cells gene signature to improve prediction of the prognosis and immune response of uveal melanoma

Y Sun, J Wu, Y Yuan, Y Lu, M Luo, L Lin… - Frontiers in cell and …, 2021 - frontiersin.org
Background CD8+ T cells work as a key effector of adaptive immunity and are closely
associated with immune response for killing tumor cells. It is crucial to understand the role of …

Bioinformatic Analysis Reveals Central Role for Tumor‐Infiltrating Immune Cells in Uveal Melanoma Progression

M Lachota, A Lennikov, KJ Malmberg… - Journal of …, 2021 - Wiley Online Library
Tumor‐infiltrating immune cells are capable of effective cancer surveillance, and their
abundance is linked to better prognosis in numerous tumor types. However, in uveal …

Identification of prognostic genes in uveal melanoma microenvironment

H Luo, C Ma - PLoS One, 2020 - journals.plos.org
Background Uveal melanoma (UM) is the most common primary intraocular malignancy in
adults. Many previous studies have demonstrated that the infiltrating of immune and stromal …

Integrating Single-cell and Bulk RNA-seq to Construct a Metastasis-related Model for Evaluating Immunotherapy and Chemotherapy in Uveal Melanoma

Y Du, X Jiang, Y Zhang, J Ying… - Current Medicinal …, 2024 - ingentaconnect.com
Background: Metastasis is a major cause of death in UM, highlighting the need to use highly
specific and sensitive prognostic markers to identify patients with a risk of developing …

Immunogenic profiling of metastatic uveal melanoma discerns a potential signature related to prognosis

J Wang, M Liu, J Sun, Z Zhang - Journal of Cancer Research and Clinical …, 2024 - Springer
Background Uveal melanoma (UM) is an aggressive intraocular malignant tumor. The
present study aimed to identify the key genes associated with UM metastasis and …

Single-cell hdWGCNA reveals metastatic protective macrophages and development of deep learning model in uveal melanoma

Y Sun, J Wu, Q Zhang, P Wang, J Zhang… - Journal of Translational …, 2024 - Springer
Background Although there has been some progress in the treatment of primary uveal
melanoma (UVM), distant metastasis remains the leading cause of death in patients …

Integrated analysis reveals the dysfunction of signaling pathways in uveal melanoma

S Sun, B Guo, L Xu, R Shi - BMC cancer, 2022 - Springer
Background Uveal melanoma (UM) is the most common primary intraocular malignancy with
a strong tendency to metastasize. The prognosis is poor once metastasis occurs. The …

Identification of survival-related genes and a novel gene-based prognostic signature involving the tumor microenvironment of uveal melanoma

S Lei, Y Zhang - International Immunopharmacology, 2021 - Elsevier
Uveal melanoma (UM) is the most common primary intraocular malignant tumor in adults
and almost fifty percent of patients subsequently develop systemic metastases usually …