An unusual Dicer-like1 protein fuels the RNA interference pathway in Trypanosoma brucei
H Shi, C Tschudi, E Ullu - Rna, 2006 - rnajournal.cshlp.org
RNA interference (RNAi) is an evolutionarily conserved gene-silencing pathway that is
triggered by double-stranded RNA (dsRNA). Central to this pathway are two ribonucleases …
triggered by double-stranded RNA (dsRNA). Central to this pathway are two ribonucleases …
Distinct and overlapping roles for two Dicer-like proteins in the RNA interference pathways of the ancient eukaryote Trypanosoma brucei
KL Patrick, H Shi, NG Kolev, K Ersfeld… - Proceedings of the …, 2009 - National Acad Sciences
Trypanosoma brucei is one of the most ancient eukaryotes where RNA interference (RNAi)
is operational and is the only single-cell pathogen where RNAi has been extensively studied …
is operational and is the only single-cell pathogen where RNAi has been extensively studied …
Small interfering RNA-producing loci in the ancient parasitic eukaryote Trypanosoma brucei
C Tschudi, H Shi, JB Franklin, E Ullu - BMC genomics, 2012 - Springer
Background At the core of the RNA interference (RNAi) pathway in Trypanosoma brucei is a
single Argonaute protein, Tb AGO1, with an established role in controlling retroposon and …
single Argonaute protein, Tb AGO1, with an established role in controlling retroposon and …
Structure of the human Dicer-TRBP complex by electron microscopy
PW Lau, CS Potter, B Carragher, IJ MacRae - Structure, 2009 - cell.com
Dicer is a specialized ribonuclease that initiates RNA interference (RNAi) by cleaving
double-stranded RNA (dsRNA) into small RNA fragments about 22 nucleotides long. Here …
double-stranded RNA (dsRNA) into small RNA fragments about 22 nucleotides long. Here …
Functional replacement of Trypanosoma brucei Argonaute by the human slicer Argonaute2
H Shi, C Tschudi, E Ullu - Rna, 2006 - rnajournal.cshlp.org
RNA interference (RNAi) is widespread throughout the eukaryotic lineage, from protozoa to
man. Central to all RNAi phenomena is a member of the Argonaute protein family, and, in …
man. Central to all RNAi phenomena is a member of the Argonaute protein family, and, in …
Structure of Dicer and mechanistic implications for RNAi
Dicer is a specialized ribonuclease that processes double-stranded RNA (dsRNA) into small
RNA fragments about25 nucleotides in length during the initiation phase of RNA …
RNA fragments about25 nucleotides in length during the initiation phase of RNA …
Functional analysis of dicer-2 missense mutations in the siRNA pathway of Drosophila
The Drosophila RNase III enzyme Dicer-2 processes double-stranded RNA (dsRNA)
precursors into small interfering RNAs (siRNAs). It also interacts with the siRNA product and …
precursors into small interfering RNAs (siRNAs). It also interacts with the siRNA product and …
In vitro synthesized small interfering RNAs elicit RNA interference in african trypanosomes: an in vitro and in vivo analysis
A Best, L Handoko, E Schlüter, HU Goringer - Journal of Biological …, 2005 - ASBMB
RNA interference (RNAi) describes an epigenetic gene silencing reaction by which gene-
specific double-stranded RNA acts as a trigger to induce the ribonucleolytic degradation of …
specific double-stranded RNA acts as a trigger to induce the ribonucleolytic degradation of …
Schistosoma mansoni: the dicer gene and its expression
G Krautz-Peterson, PJ Skelly - Experimental parasitology, 2008 - Elsevier
RNA interference (RNAi) is a gene silencing mechanism that plays an important role in
regulating gene expression in many eukaryotes and has become a valuable molecular tool …
regulating gene expression in many eukaryotes and has become a valuable molecular tool …
A glimpse of “Dicer Biology” through the structural and functional perspective
S Paturi, MV Deshmukh - Frontiers in molecular biosciences, 2021 - frontiersin.org
The RNA interference pathway (RNAi) is executed by two core enzymes, Dicer and
Argonaute, for accomplishing a tailored transcriptional and post-transcriptional gene …
Argonaute, for accomplishing a tailored transcriptional and post-transcriptional gene …