[HTML][HTML] A bispecific antibody exhibits broad neutralization against SARS-CoV-2 Omicron variants XBB. 1.16, BQ. 1.1 and sarbecoviruses

Y Wang, A Hao, P Ji, Y Ma, Z Zhang, J Chen… - Nature …, 2024 - nature.com
Abstract The Omicron subvariants BQ. 1.1, XBB. 1.5, and XBB. 1.16 of SARS-CoV-2 are
known for their adeptness at evading immune responses. Here, we isolate a neutralizing …

[PDF][PDF] Atlas of currently available human neutralizing antibodies against SARS-CoV-2 and escape by Omicron sub-variants BA. 1/BA. 1.1/BA. 2/BA. 3

M Huang, L Wu, A Zheng, Y Xie, Q He, X Rong, P Han… - Immunity, 2022 - cell.com
SARS-CoV-2 Omicron variant has presented significant challenges to current antibodies
and vaccines. Herein, we systematically compared the efficacy of 50 human monoclonal …

[HTML][HTML] Neutralization sensitivity of SARS-CoV-2 Omicron variants FL. 1 and GE. 1 by therapeutic antibodies and XBB sera

J Lee, Y Naoe, U Bang, Y Nakagama, A Saito, Y Kido… - Virology, 2024 - Elsevier
Abstract Two SARS-CoV-2 XBB sub-variants, FL. 1 and GE. 1, have been increasing in
prevalence worldwide, but limited information is available about their ability to evade the …

[HTML][HTML] Identification of a highly conserved neutralizing epitope within the RBD region of diverse SARS-CoV-2 variants

Y Wang, A Yan, D Song, M Duan, C Dong… - Nature …, 2024 - nature.com
The constant emergence of SARS-CoV-2 variants continues to impair the efficacy of existing
neutralizing antibodies, especially XBB. 1.5 and EG. 5, which showed exceptional immune …

A bispecific antibody targeting RBD and S2 potently neutralizes SARS-CoV-2 Omicron and other variants of concern

M Yuan, X Chen, Y Zhu, X Dong, Y Liu, Z Qian… - Journal of …, 2022 - Am Soc Microbiol
Emerging severe acute respiratory syndrome coronavirus type 2 (SARS-CoV-2) variants,
especially the Omicron variant, have impaired the efficacy of existing vaccines and most …

[HTML][HTML] Combating the SARS-CoV-2 Omicron (BA. 1) and BA. 2 with potent bispecific antibodies engineered from non-Omicron neutralizing antibodies

Y Wang, X Zhang, Y Ma, Y Wang, W Zhan, Q Zheng… - Cell Discovery, 2022 - nature.com
The highly mutated and transmissible Omicron (BA. 1) and its more contagious lineage BA.
2 have provoked serious concerns over their decreased sensitivity to the current COVID-19 …

Structural insights for neutralization of Omicron variants BA. 1, BA. 2, BA. 4, and BA. 5 by a broadly neutralizing SARS-CoV-2 antibody

S Kumar, A Patel, L Lai, C Chakravarthy… - Science …, 2022 - science.org
In this study, by characterizing several human monoclonal antibodies (mAbs) isolated from
single B cells of the COVID-19–recovered individuals in India who experienced ancestral …

[PDF][PDF] Neutralization of SARS-CoV-2 BA. 2.86 and JN. 1 by CF501 adjuvant-enhanced immune responses targeting the conserved epitopes in ancestral RBD

Z Liu, J Zhou, W Wang, G Zhang, L Xing, K Zhang… - Cell Reports …, 2024 - cell.com
The emerged severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron
subvariants BA. 2.86 and JN. 1 raise concerns regarding their potential to evade immune …

[HTML][HTML] Biparatopic antibody BA7208/7125 effectively neutralizes SARS-CoV-2 variants including Omicron BA. 1-BA. 5

Y Wang, A Yan, D Song, C Dong, M Rao, Y Gao, R Qi… - Cell Discovery, 2023 - nature.com
SARS-CoV-2 Omicron subvariants have demonstrated extensive evasion from monoclonal
antibodies (mAbs) developed for clinical use, which raises an urgent need to develop new …

[PDF][PDF] Omicron BQ. 1.1 and XBB. 1 unprecedentedly escape broadly neutralizing antibodies elicited by prototype vaccination

B Ju, Q Fan, C Liu, S Shen, M Wang, H Guo, B Zhou… - Cell Reports, 2023 - cell.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) Omicron subvariants have
seriously attacked the antibody barrier established by natural infection and/or vaccination …