[HTML][HTML] Molecular determinants of nephron vascular specialization in the kidney
Although kidney parenchymal tissue can be generated in vitro, reconstructing the complex
vasculature of the kidney remains a daunting task. The molecular pathways that specify and …
vasculature of the kidney remains a daunting task. The molecular pathways that specify and …
Spatiotemporal heterogeneity and patterning of developing renal blood vessels
E Daniel, DB Azizoglu, AR Ryan, TA Walji, CP Chaney… - Angiogenesis, 2018 - Springer
The kidney vasculature facilitates the excretion of wastes, the dissemination of hormones,
and the regulation of blood chemistry. To carry out these diverse functions, the vasculature is …
and the regulation of blood chemistry. To carry out these diverse functions, the vasculature is …
Conserved and divergent molecular and anatomic features of human and mouse nephron patterning
NO Lindström, T Tran, J Guo, E Rutledge… - Journal of the …, 2018 - journals.lww.com
The nephron is the functional unit of the kidney, but the mechanism of nephron formation
during human development is unclear. We conducted a detailed analysis of nephron …
during human development is unclear. We conducted a detailed analysis of nephron …
[HTML][HTML] Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets
Determining the epigenetic program that generates unique cell types in the kidney is critical
for understanding cell-type heterogeneity during tissue homeostasis and injury response …
for understanding cell-type heterogeneity during tissue homeostasis and injury response …
A reference tissue atlas for the human kidney
Kidney Precision Medicine Project (KPMP) is building a spatially specified human kidney
tissue atlas in health and disease with single-cell resolution. Here, we describe the …
tissue atlas in health and disease with single-cell resolution. Here, we describe the …
Vascular heterogeneity in the kidney
G Molema, WC Aird - Seminars in nephrology, 2012 - Elsevier
Blood vessels and their endothelial lining are uniquely adapted to the needs of the
underlying tissue. The structure and function of the vasculature varies both between and …
underlying tissue. The structure and function of the vasculature varies both between and …
Conserved and divergent features of human and mouse kidney organogenesis
NO Lindström, JA McMahon, J Guo, T Tran… - Journal of the …, 2018 - journals.lww.com
Human kidney function is underpinned by approximately 1,000,000 nephrons, although the
number varies substantially, and low nephron number is linked to disease. Human kidney …
number varies substantially, and low nephron number is linked to disease. Human kidney …
[HTML][HTML] Ablation of the renal stroma defines its critical role in nephron progenitor and vasculature patterning
S Hum, C Rymer, C Schaefer, D Bushnell… - PloS one, 2014 - journals.plos.org
The renal stroma is an embryonic cell population located in the cortex that provides a
structural framework as well as a source of endothelial progenitors for the developing …
structural framework as well as a source of endothelial progenitors for the developing …
[HTML][HTML] Nephron Patterning: Lessons from Xenopus, Zebrafish, and Mouse Studies
A Desgrange, S Cereghini - Cells, 2015 - mdpi.com
The nephron is the basic structural and functional unit of the vertebrate kidney. To ensure
kidney functions, the nephrons possess a highly segmental organization where each …
kidney functions, the nephrons possess a highly segmental organization where each …
Principles of human and mouse nephron development
J Schnell, MA Achieng, NO Lindström - Nature Reviews Nephrology, 2022 - nature.com
The mechanisms underlying kidney development in mice and humans is an area of intense
study. Insights into kidney organogenesis have the potential to guide our understanding of …
study. Insights into kidney organogenesis have the potential to guide our understanding of …