Application of model-based approaches to evaluate hepatic transporter-mediated drug clearance: in vitro, in vivo, and in vitro-in vivo extrapolation
Z Liu, K Liu - Current drug metabolism, 2016 - ingentaconnect.com
Background: Hepatic transporters, including efflux transporters and uptake transporters,
have been recognized to play an important role in the disposition of various drugs. These …
have been recognized to play an important role in the disposition of various drugs. These …
Transporter–enzyme interplay and the hepatic drug clearance: what have we learned so far?
Introduction: Transporters and enzymes play an important role in absorption, distribution,
clearance and elimination of drugs. Areas covered: This review provides an overview of the …
clearance and elimination of drugs. Areas covered: This review provides an overview of the …
Simultaneous assessment in vitro of transporter and metabolic processes in hepatic drug clearance: use of a media loss approach
Hepatocyte drug depletion-time assays are well established for determination of metabolic
clearance in vitro. The present study focuses on the refinement and evaluation of a “media …
clearance in vitro. The present study focuses on the refinement and evaluation of a “media …
In vitro and in vivo approaches to characterize transporter-mediated disposition in drug discovery
Introduction: It is becoming increasingly evident that transporters play an important role in
the absorption, distribution and elimination of many drugs. Different approaches have been …
the absorption, distribution and elimination of many drugs. Different approaches have been …
In vitro–in vivo extrapolation of hepatic clearance involving active uptake: Theoretical and experimental aspects
PJH Webborn, AJ Parker, RL Denton, RJ Riley - Xenobiotica, 2007 - Taylor & Francis
The importance of hepatic uptake transporters in drug clearance is well recognized. The
subject is reviewed with the intention of providing an overview of the concepts in order to link …
subject is reviewed with the intention of providing an overview of the concepts in order to link …
Predicting human hepatic clearance from in vitro drug metabolism and transport data: a scientific and pharmaceutical perspective for assessing drug–drug …
G Camenisch, K Umehara - Biopharmaceutics & drug …, 2012 - Wiley Online Library
Objectives Membrane transporters and metabolism are major determinants of the
hepatobiliary elimination of drugs. This work investigates several key questions for drug …
hepatobiliary elimination of drugs. This work investigates several key questions for drug …
Model-based approaches to predict drug–drug interactions associated with hepatic uptake transporters: preclinical, clinical and beyond
Introduction: Membrane transporters have been recognized to play a key role in determining
the absorption, distribution and elimination processes of drugs. The organic anion …
the absorption, distribution and elimination processes of drugs. The organic anion …
Prediction of pharmacokinetics and drug–drug interactions when hepatic transporters are involved
Hepatobiliary transport mechanisms have been identified to play a significant role in
determining the systemic clearance for a number of widely prescribed drugs and an …
determining the systemic clearance for a number of widely prescribed drugs and an …
Cynomolgus monkey as an emerging animal model to study drug transporters: in vitro, in vivo, in vitro-to-in vivo translation
H Shen, Z Yang, AD Rodrigues - Drug Metabolism and Disposition, 2022 - ASPET
Membrane transporters have been recognized as one of the key determinants of
pharmacokinetics and are also known to affect the efficacy and toxicity of drugs. Both …
pharmacokinetics and are also known to affect the efficacy and toxicity of drugs. Both …
Rationalizing underprediction of drug clearance from enzyme and transporter kinetic data: from in vitro tools to mechanistic modeling
A Galetin - Enzyme kinetics in drug metabolism: fundamentals and …, 2014 - Springer
Over the years, there has been an increase in the number and quality of available in vitro
tools for the assessment of clearance. Complexity of data analysis and modelling of …
tools for the assessment of clearance. Complexity of data analysis and modelling of …
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- uptake transporters drug interactions
- pharmacokinetics and drug hepatic transporters
- active uptake hepatic clearance
- drug clearance enzyme interplay
- drug clearance simultaneous assessment
- drug clearance mechanistic modeling
- drug clearance metabolic processes
- cynomolgus monkey drug transporters
- drug interactions hepatic transporters
- prediction of pharmacokinetics hepatic transporters