Hyperactivity of Mek in TNS1 knockouts leads to potential treatments for cystic kidney diseases
Cystic kidney disease is the progressive development of multiple fluid-filled cysts that may
severely compromise kidney functions and lead to renal failure. TNS1 (tensin-1) knockout …
severely compromise kidney functions and lead to renal failure. TNS1 (tensin-1) knockout …
[HTML][HTML] C-terminal tensin-like (CTEN) knockin alleviates cystic kidney defects in Tensin-1 knockout mice
Tensin-1 (TNS1) is a 220 kD focal adhesion protein that binds to actin filaments, integrin
receptors, small GTPases, tyrosinephosphorylated proteins, and lipids. 1 These binding …
receptors, small GTPases, tyrosinephosphorylated proteins, and lipids. 1 These binding …
[HTML][HTML] Netrin-1 Overexpression Induces Polycystic Kidney Disease: A Novel Mechanism Contributing to Cystogenesis in Autosomal Dominant Polycystic Kidney …
R Mohamed, Y Liu, AD Kistler, PC Harris… - The American Journal of …, 2022 - Elsevier
Despite recent advances in understanding the pathogenesis of polycystic kidney disease
(PKD), the underlying molecular mechanisms involved in cystogenesis are not fully …
(PKD), the underlying molecular mechanisms involved in cystogenesis are not fully …
Loss of Tsc1, but not Pten, in renal tubular cells causes polycystic kidney disease by activating mTORC1
Tuberous sclerosis complex (TSC) is a genetic disorder linked to mutations of either the
TSC1 or TSC2 gene, which encode proteins that form a complex to negatively regulate …
TSC1 or TSC2 gene, which encode proteins that form a complex to negatively regulate …
Tsc2 mutation induces renal tubular cell nonautonomous disease
TSC renal cystic disease is poorly understood and has no approved treatment. In a new
principal cell-targeted murine model of Tsc cystic disease, the renal cystic epithelium is …
principal cell-targeted murine model of Tsc cystic disease, the renal cystic epithelium is …
The MEK inhibitor trametinib ameliorates kidney fibrosis by suppressing ERK1/2 and mTORC1 signaling
P Andrikopoulos, J Kieswich, S Pacheco… - Journal of the …, 2019 - journals.lww.com
Background During kidney fibrosis, a hallmark and promoter of CKD (regardless of the
underlying renal disorder leading to CKD), the extracellular-regulated kinase 1/2 (ERK1/2) …
underlying renal disorder leading to CKD), the extracellular-regulated kinase 1/2 (ERK1/2) …
mTOR activation initiates renal cell carcinoma development by coordinating ERK and p38MAPK
H Wu, D He, S Biswas, M Shafiquzzaman, X Zhou… - Cancer Research, 2021 - AACR
Renal cell carcinoma (RCC) mainly originates from renal proximal tubules. Intriguingly,
disruption of genes frequently mutated in human RCC samples thus far has only generated …
disruption of genes frequently mutated in human RCC samples thus far has only generated …
Blocking rpS6 phosphorylation exacerbates Tsc1 deletion–induced kidney growth
The molecular mechanisms underlying renal growth and renal growth–induced nephron
damage remain poorly understood. Here, we report that in murine models, deletion of the …
damage remain poorly understood. Here, we report that in murine models, deletion of the …
Not all kidney cysts are created equal: a distinct renal cystogenic mechanism in tuberous sclerosis complex (TSC)
M Soleimani - Frontiers in Physiology, 2023 - frontiersin.org
Tuberous Sclerosis Complex (TSC) is an autosomal dominant genetic disease caused by
mutations in either TSC1 or TSC2 genes. Approximately, two million individuals suffer from …
mutations in either TSC1 or TSC2 genes. Approximately, two million individuals suffer from …
Notch transactivates Rheb to maintain the multipotency of TSC-null cells
Differentiation abnormalities are a hallmark of tuberous sclerosis complex (TSC)
manifestations; however, the genesis of these abnormalities remains unclear. Here we …
manifestations; however, the genesis of these abnormalities remains unclear. Here we …