Background: Mural cells in ascending aortic aneurysms undergo phenotypic changes that
promote extracellular matrix destruction and structural weakening. To explore this biology …

The aorta is highly heterogeneous, containing many different types of cells that perform
sophisticated functions to maintain aortic homeostasis. Recently, single-cell RNA …

Thoracic aortic aneurysm is a life-threatening condition caused by weakening of the thoracic
aorta wall, often developing silently until dissection or rupture occurs. Despite substantial …

Objective: To determine cell-specific gene expression profiles that contribute to development
of abdominal aortic aneurysms (AAAs). Background: AAAs represent the most common …

Background: Ascending thoracic aortic aneurysm (ATAA) is caused by the progressive
weakening and dilatation of the aortic wall and can lead to aortic dissection, rupture, and …

Abdominal aortic aneurysm (AAA) is a common degenerative cardiovascular disease whose
pathobiology is not clearly understood. The cellular heterogeneity and cell-type-specific …

Aortic aneurysms occur in the thoracic and abdominal sections of the aorta and are a deadly
late-age-at-onset disease with complex pathobiology. Currently, the number of published …

OBJECTIVES: The purpose of this study was to profile altered patterns of gene expression
that characterize degenerative ascending thoracic aortic aneurysms and to compare these …

Aims The artery contains numerous cell types which contribute to multiple vascular
diseases. However, the heterogeneity and cellular responses of these vascular cells during …

Background and objectives Phenotypic switching in vascular smooth muscle cells (VSMCs)
has been linked to aortic aneurysm, but the phenotypic landscape in aortic aneurysm is …