SARS-CoV-2 potential drugs, drug targets, and biomarkers: a viral-host interaction network-based analysis

A Samy, MA Maher, NA Abdelsalam, E Badr - Scientific Reports, 2022 - nature.com
COVID-19 is a global pandemic impacting the daily living of millions. As variants of the virus
evolve, a complete comprehension of the disease and drug targets becomes a decisive …

Network-Based Identification and Experimental Validation of Drug Candidates Toward SARS-CoV-2 via Targeting Virus–Host Interactome

J Fang, Q Wu, F Ye, C Cai, L Xu, Y Gu, Q Wang… - Frontiers in …, 2021 - frontiersin.org
Despite that several therapeutic agents have exhibited promising prevention or treatment on
Coronavirus disease-2019 (COVID-19), there is no specific drug discovered for this …

[HTML][HTML] Network analysis and molecular mapping for SARS-CoV-2 to reveal drug targets and repurposing of clinically developed drugs

SA More, AS Patil, NS Sakle, SN Mokale - Virology, 2021 - Elsevier
Abstract Novel coronavirus (SARS–CoV–2), turned out to be a global pandemic with
unstoppable morbidity and mortality rate. However, till date there is no effective treatment …

Network pharmacology reveals multitarget mechanism of action of drugs to be repurposed for COVID-19

M Alegría-Arcos, T Barbosa, F Sepúlveda… - Frontiers in …, 2022 - frontiersin.org
The coronavirus disease 2019 pandemic accelerated drug/vaccine development processes,
integrating scientists all over the globe to create therapeutic alternatives against this virus. In …

[HTML][HTML] Drug repurposing platform for deciphering the druggable SARS-CoV-2 interactome

MS Bogacheva, S Kuivanen, S Potdar, A Hassinen… - Antiviral Research, 2024 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic has heavily challenged the
global healthcare system. Despite the vaccination programs, the new virus variants are …

Discovery of clinically approved drugs capable of inhibiting SARS-CoV-2 in vitro infection using a phenotypic screening strategy and network-analysis to predict their …

DF Sales-Medina, LRP Ferreira, LMD Romera… - BioRxiv, 2020 - biorxiv.org
The disease caused by SARS-CoV2, covid-19, rapidly spreads worldwide, causing the
greatest threat to global public health in the last 100 years. This scenario has become …

Multi-omics-based identification of SARS-CoV-2 infection biology and candidate drugs against COVID-19

D Barh, S Tiwari, ME Weener, V Azevedo… - Computers in biology …, 2020 - Elsevier
SARS-CoV-2 has ushered a global pandemic with no effective drug being available at
present. Although several FDA-approved drugs are currently under clinical trials for drug …

A systems‐level study reveals host‐targeted repurposable drugs against SARS‐CoV‐2 infection

F Chen, Q Shi, F Pei, A Vogt, RA Porritt… - Molecular systems …, 2021 - embopress.org
Understanding the mechanism of SARS‐CoV‐2 infection and identifying potential
therapeutics are global imperatives. Using a quantitative systems pharmacology approach …

Advanced bioinformatics rapidly identifies existing therapeutics for patients with coronavirus disease-2019 (COVID-19)

J Kim, J Zhang, Y Cha, S Kolitz, J Funt… - Journal of translational …, 2020 - Springer
Background The recent global pandemic has placed a high priority on identifying drugs to
prevent or lessen clinical infection of severe acute respiratory syndrome coronavirus 2 …

[HTML][HTML] Transcriptome network analyses in human coronavirus infections suggest a rational use of immunomodulatory drugs for COVID-19 therapy

HSC Wong, CL Guo, GH Lin, KY Lee, Y Okada… - Genomics, 2021 - Elsevier
The recent outbreak of coronavirus disease 2019 (COVID-19) by SARS-CoV-2 has led to
uptodate 24.3 M cases and 0.8 M deaths. It is thus in urgent need to rationalize potential …