Drug repurposing for coronavirus (SARS-CoV-2) based on gene co-expression network analysis
H MotieGhader, E Safavi, A Rezapour, FF Amoodizaj… - Scientific reports, 2021 - nature.com
Severe acute respiratory syndrome (SARS) is a highly contagious viral respiratory illness.
This illness is spurred on by a coronavirus known as SARS-associated coronavirus (SARS …
This illness is spurred on by a coronavirus known as SARS-associated coronavirus (SARS …
MCCS: a novel recognition pattern-based method for fast track discovery of anti-SARS-CoV-2 drugs
Given the scale and rapid spread of the coronavirus disease 2019 (COVID-19) caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, or 2019-nCoV), there is an …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, or 2019-nCoV), there is an …
Network neighbors of viral targets and differentially expressed genes in COVID-19 are drug target candidates
The COVID-19 pandemic is raging. It revealed the importance of rapid scientific
advancement towards understanding and treating new diseases. To address this challenge …
advancement towards understanding and treating new diseases. To address this challenge …
Machine learning–based integration of network features and chemical structure of compounds for SARS‐CoV‐2 drug effect analysis
High drug development costs and the limited number of new annual drug approvals
increase the need for innovative approaches for drug effect prediction. Severe acute …
increase the need for innovative approaches for drug effect prediction. Severe acute …
Molecular targets and system biology approaches for drug repurposing against SARS-CoV-2
Background COVID-19, a pandemic declared by WHO, has infected about 39.5 million and
killed about 1.1 million people throughout the world. There is the urgent need of more …
killed about 1.1 million people throughout the world. There is the urgent need of more …
COVID19db: a comprehensive database platform to discover potential drugs and targets of COVID-19 at whole transcriptomic scale
W Zhang, Y Zhang, Z Min, J Mo, Z Ju… - Nucleic acids …, 2022 - academic.oup.com
Many open access transcriptomic data of coronavirus disease 2019 (COVID-19) were
generated, they have great heterogeneity and are difficult to analyze. To utilize these …
generated, they have great heterogeneity and are difficult to analyze. To utilize these …
Executable network of SARS-CoV-2-host interaction predicts drug combination treatments
R Howell, MA Clarke, AK Reuschl, T Chen… - NPJ Digital …, 2022 - nature.com
The COVID-19 pandemic has pushed healthcare systems globally to a breaking point. The
urgent need for effective and affordable COVID-19 treatments calls for repurposing …
urgent need for effective and affordable COVID-19 treatments calls for repurposing …
Causal network models of SARS-CoV-2 expression and aging to identify candidates for drug repurposing
Given the severity of the SARS-CoV-2 pandemic, a major challenge is to rapidly repurpose
existing approved drugs for clinical interventions. While a number of data-driven and …
existing approved drugs for clinical interventions. While a number of data-driven and …
Integrative transcriptome analyses empower the anti-COVID-19 drug arsenal
The beginning of the 21st century has been marked by three distinct waves of zoonotic
coronavirus outbreaks into the human population. The COVID-19 (coronavirus disease …
coronavirus outbreaks into the human population. The COVID-19 (coronavirus disease …
Identifying potential novel insights for COVID-19 pathogenesis and therapeutics using an integrated bioinformatics analysis of host transcriptome
SA El-Aarag, A Mahmoud, M ElHefnawi - International Journal of Biological …, 2022 - Elsevier
The molecular mechanisms underlying the pathogenesis of COVID-19 have not been fully
discovered. This study aims to decipher potentially hidden parts of the pathogenesis of …
discovered. This study aims to decipher potentially hidden parts of the pathogenesis of …