A SARS-CoV-2 (COVID-19) biological network to find targets for drug repurposing

M Habibi, G Taheri, R Aghdam - Scientific reports, 2021 - nature.com
Abstract The Coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 virus
needs a fast recognition of effective drugs to save lives. In the COVID-19 situation, finding …

A BioID-derived proximity interactome for SARS-CoV-2 proteins

DG May, L Martin-Sancho, V Anschau, S Liu… - Viruses, 2022 - mdpi.com
The novel coronavirus SARS-CoV-2 is responsible for the ongoing COVID-19 pandemic and
has caused a major health and economic burden worldwide. Understanding how SARS …

Pathogenesis and Management of COVID-19

KO Alfarouk, STS AlHoufie, SBM Ahmed… - Journal of …, 2021 - mdpi.com
COVID-19, occurring due to SARS-COV-2 infection, is the most recent pandemic disease
that has led to three million deaths at the time of writing. A great deal of effort has been …

Strategies for the development of drugs targeting novel coronavirus 2019-nCoV.

QY Liu, XL Wang - 2020 - cabidigitallibrary.org
There is no specific drug that has been approved for 2019-nCoV. There are a number of
factors that pose major challenges in their development. Approaches to the development of …

Exploring the SARS-CoV-2 proteome in the search of potential inhibitors via structure-based pharmacophore modeling/docking approach

G Culletta, MR Gulotta, U Perricone, M Zappalà… - Computation, 2020 - mdpi.com
To date, SARS-CoV-2 infectious disease, named COVID-19 by the World Health
Organization (WHO) in February 2020, has caused millions of infections and hundreds of …

Machine learning identifies molecular regulators and therapeutics for targeting SARS‐CoV2‐induced cytokine release

M Chan, S Vijay, J McNevin, MJ McElrath… - Molecular systems …, 2021 - embopress.org
Abstract Although 15–20% of COVID‐19 patients experience hyper‐inflammation induced
by massive cytokine production, cellular triggers of this process and strategies to target them …

A connectivity map-based drug repurposing study and integrative analysis of transcriptomic profiling of SARS-CoV-2 infection

SZ Mousavi, M Rahmanian, A Sami - Infection, Genetics and Evolution, 2020 - Elsevier
Aims The recent outbreak of COVID-19 has become a global health concern. There are
currently no effective treatment strategies and vaccines for the treatment or prevention of this …

Bioinformatics and system biology approach to identify the influences among COVID-19, ARDS and sepsis

P Li, T Li, Z Zhang, X Dai, B Zeng, Z Li, Z Li - Frontiers in Immunology, 2023 - frontiersin.org
Background Severe coronavirus disease 2019 (COVID-19) has led to severe pneumonia or
acute respiratory distress syndrome (ARDS) worldwide. we have noted that many critically ill …

[HTML][HTML] Atlas of interactions between SARS-CoV-2 macromolecules and host proteins

G Li, Z Tang, W Fan, X Wang, L Huang, Y Jia, M Wang… - Cell Insight, 2023 - Elsevier
The proteins and RNAs of viruses extensively interact with host proteins after infection. We
collected and reanalyzed all available datasets of protein-protein and RNA-protein …

Pathogenetic profiling of COVID-19 and SARS-like viruses

Z Nain, HK Rana, P Liò, SMS Islam… - Briefings in …, 2021 - academic.oup.com
Abstract The novel coronavirus (2019-nCoV) has recently emerged, causing COVID-19
outbreaks and significant societal/global disruption. Importantly, COVID-19 infection …