Emerging integrated SERS-microfluidic devices for analysis of cancer-derived small extracellular vesicles

L Ngo, A Tukova, A Hassanzadeh-Barforoushi… - Lab on a Chip, 2023 - pubs.rsc.org
Cancer-derived small extracellular vesicles (sEVs) are specific subgroups of lipid bilayer
vesicles secreted from cancer cells to the extracellular environment. They carry distinct …

An integrated sample-to-answer SERS platform for multiplex phenotyping of extracellular vesicles

W Lin, L Yuan, Z Gao, G Cai, C Liang, M Fan… - Sensors and Actuators B …, 2023 - Elsevier
Tumor-derived extracellular vesicles (EVs) are emerging as a non-invasive liquid biopsy
marker for cancer diagnosis and treatment monitoring. However, clinical detection …

Enabling sensitive phenotypic profiling of cancer-derived small extracellular vesicles using surface-enhanced Raman spectroscopy nanotags

W Zhang, L Jiang, RJ Diefenbach, DH Campbell… - ACS …, 2020 - ACS Publications
Circulating cancer-derived small extracellular vesicles (EVs) are nanoscale membranous
vesicles shed from cancer cells that are released into surrounding body fluids. Small EVs …

Sensitive phenotyping of serum extracellular vesicles on a SERS-microfluidic platform for early-stage clinical diagnosis of ovarian carcinoma

X Chen, J Tang, Y Zhao, R Wang, S Sang, F Yu… - Biosensors and …, 2025 - Elsevier
Ovarian carcinoma (OvCa) poses a severe threat to women's health due to its high mortality
rate and lack of efficient early diagnosis approach. There is evidence to suggest that …

Improving SERS biosensors for the analysis of ovarian cancer-derived small extracellular vesicles

L Ngo, W Zhang, SST Hnit, Y Wang - Analyst, 2023 - pubs.rsc.org
Small extracellular vesicles (sEVs) are lipid bilayer vesicles that carry key molecules (eg,
proteins, DNAs, RNAs, and lipids) for cell-to-cell communication, being regarded as …

Advanced microfluidic technologies for isolating extracellular vesicles

S Zhang, J Deng, J Li, F Tian, C Liu, L Fang… - TrAC Trends in Analytical …, 2022 - Elsevier
Extracellular vesicles (EVs) are lipid membrane-enclosed, cell-secreted nanovesicles that
have attracted significant attentions in recent years in view of their potential as non-invasive …

Microfluidic approaches for isolation, detection, and characterization of extracellular vesicles: Current status and future directions

S Gholizadeh, MS Draz, M Zarghooni… - Biosensors and …, 2017 - Elsevier
Extracellular vesicles (EVs) are cell-derived vesicles present in body fluids that play an
essential role in various cellular processes, such as intercellular communication …

Microfluidic platforms for extracellular vesicle isolation, analysis and therapy in cancer

CM Abreu, B Costa-Silva, RL Reis, SC Kundu… - Lab on a Chip, 2022 - pubs.rsc.org
Extracellular vesicles (EVs) are small lipidic particles packed with proteins, DNA, messenger
RNA and microRNAs of their cell of origin that act as critical players in cell–cell …

An integrated microfluidic‐SERS platform enables sensitive phenotyping of serum extracellular vesicles in early stage melanomas

J Wang, YC Kao, Q Zhou, A Wuethrich… - Advanced Functional …, 2022 - Wiley Online Library
Precise detection of early melanomas is essential as the stage of disease guides treatment
options. One growing field that may facilitate the advancement of early melanoma detection …

Analysis of extracellular vesicles as emerging theranostic nanoplatforms

Y Xing, Z Cheng, R Wang, C Lv, TD James… - Coordination Chemistry …, 2020 - Elsevier
Extracellular vesicles (EVs) are nanoscale lipid membrane–bound vesicles that are secreted
by cells of both prokaryotes and eukaryotes and carry bioactive cargos including proteins …