Alpha-lipoic acid shows promise to improve migraine in patients with insulin resistance: a 6-month exploratory study

C Cavestro, G Bedogni, F Molinari… - Journal of medicinal …, 2018 - liebertpub.com
Alpha-lipoic acid (ALA) is known to lower insulin resistance (IR), which is common among
migraineurs. To assess the effect of ALA on headache in migraineurs with IR, we performed …

The beneficial effect of Alpha-lipoic acid supplementation as a potential adjunct treatment in episodic migraines

MR Kelishadi, AA Naeini, F Khorvash, G Askari… - Scientific reports, 2022 - nature.com
The current study was performed to evaluate the effects of alpha-lipoic acid (ALA)
supplementation on lactate, nitric oxide (NO), vascular cell adhesion molecule-1 (VCAM-1) …

The efficacy of alpha‐lipoic acid in improving oxidative, inflammatory, and mood status in women with episodic migraine in a randomised, double‐blind, placebo …

M Rezaei Kelishadi, A Alavi Naeini… - … Journal of Clinical …, 2021 - Wiley Online Library
Aim Migraine is a common neurovascular disorder, which is associated with severe to
moderate disabling headaches. Oxidative stress and inflammation might play a role in …

Topically applied linoleic/linolenic acid for chronic migraine

C Santos, DF Weaver - Journal of Clinical Neuroscience, 2018 - Elsevier
The topical application of linoleic and linolenic acids is a potential prophylactic approach to
migraine via an anti-inflammatory mechanism. We present a 45-year-old woman with …

Impact of Fatty Acid Supplementation on Migraine Outcomes: A Systematic Review and Meta-analysis

G García-Pérez-de-Sevilla… - Nutrition …, 2025 - academic.oup.com
Context Migraines are a prevalent neurological condition that significantly impacts the
quality of life. Although narrative reviews and clinical trials suggest the potential effects of …

Evaluation of Safety and Efficacy of Add‐on Alpha‐Lipoic Acid on Migraine Prophylaxis in an Adolescent Population: A Randomized Controlled Trial

HM Puliappadamb, AK Satpathy… - The Journal of …, 2023 - Wiley Online Library
Nutraceuticals like alpha‐lipoic acid (ALA) may have potential benefits as prophylactic
agents for adolescent migraine, with fewer adverse events than existing medications. The …

Effectiveness of Palmitoylethanolamide (Levagen+) Compared to a Placebo for Reducing Pain, Duration, and Medication Use during Migraines in Otherwise Healthy …

D Briskey, R Skinner, C Smith, A Rao - Pharmaceuticals, 2024 - mdpi.com
Migraines are a common neurological disorder that generally affects young to middle-aged
adults and females more than males. Various treatment options are available; however …

[HTML][HTML] Safety and efficacy of alpha-lipoic acid oral supplementation in the reduction of pain with unknown etiology: A monocentric, randomized, double-blind …

C Esposito, EU Garzarella, C Santarcangelo… - Biomedicine & …, 2021 - Elsevier
Introduction Extensive evidence suggests that alpha-lipoic acid (ALA) is effective in diabetic
neuropathy pain management. However, little is known on its safety and efficacy in reducing …

Dietary alteration of n-3 and n-6 fatty acids for headache reduction in adults with migraine: Randomized controlled trial

CE Ramsden, D Zamora, KR Faurot, B MacIntosh… - bmj, 2021 - bmj.com
Objective To determine whether dietary interventions that increase n-3 fatty acids with and
without reduction in n-6 linoleic acid can alter circulating lipid mediators implicated in …

A sixteen-week three-armed, randomized, controlled trial investigating clinical and biochemical effects of targeted alterations in dietary linoleic acid and n-3 EPA+ …

JD Mann, KR Faurot, B MacIntosh, OS Palsson… - … and Essential Fatty …, 2018 - Elsevier
Migraine is a prevalent neurological disorder, affecting over 16% of adult women and 7% of
adult men in the US, causing significant pain, disability, and medical expense, with …