Genomewide DNA methylation analysis reveals novel targets for drug development in mantle cell lymphoma

VV Leshchenko, PY Kuo, R Shaknovich… - Blood, The Journal …, 2010 - ashpublications.org
Mantle cell lymphoma (MCL) is a mostly incurable malignancy arising from naive B cells
(NBCs) in the mantle zone of lymph nodes. We analyzed genomewide methylation in MCL …

Identification of methylated genes associated with aggressive clinicopathological features in mantle cell lymphoma

A Enjuanes, V Fernandez, L Hernández, A Navarro… - PLoS …, 2011 - journals.plos.org
Background Mantle cell lymphoma (MCL) is genetically characterized by the t (11; 14)(q13;
q32) translocation and a high number of secondary chromosomal alterations. The …

Mantle cell lymphoma displays a homogenous methylation profile: a comparative analysis with chronic lymphocytic leukemia

AM Halldórsdóttir, M Kanduri… - American journal of …, 2012 - Wiley Online Library
Mantle cell lymphoma (MCL) and chronic lymphocytic leukemia (CLL) are mature CD5+ B‐
cell malignancies with different biological/clinical characteristics. We recently reported an …

Decoding the DNA methylome of mantle cell lymphoma in the light of the entire B cell lineage

AC Queiros, R Beekman, R Vilarrasa-Blasi… - Cancer cell, 2016 - cell.com
We analyzed the in silico purified DNA methylation signatures of 82 mantle cell lymphomas
(MCL) in comparison with cell subpopulations spanning the entire B cell lineage. We …

Genomic and epigenomic insights into the origin, pathogenesis, and clinical behavior of mantle cell lymphoma subtypes

F Nadeu, D Martin-Garcia, G Clot… - Blood, The Journal …, 2020 - ashpublications.org
Mantle cell lymphoma (MCL) is a mature B-cell neoplasm initially driven by CCND1
rearrangement with 2 molecular subtypes, conventional MCL (cMCL) and leukemic non …

Genomic and transcriptomic profiling reveals distinct molecular subsets associated with outcomes in mantle cell lymphoma

S Yi, Y Yan, M Jin, S Bhattacharya… - The Journal of …, 2022 - Am Soc Clin Investig
Mantle cell lymphoma (MCL) is a phenotypically and genetically heterogeneous malignancy
in which the genetic alterations determining clinical indications are not fully understood …

[HTML][HTML] Single-cell RNA-seq reveals the immune escape and drug resistance mechanisms of mantle cell lymphoma

L Wang, S Mo, X Li, Y He, J Yang - Cancer biology & medicine, 2020 - ncbi.nlm.nih.gov
Objective: Mantle cell lymphoma (MCL) is a rare subtype of non-Hodgkin lymphoma (NHL)
with high heterogeneity and a high recurrence rate. How heterogenous cell populations …

Coding and noncoding drivers of mantle cell lymphoma identified through exome and genome sequencing

P Pararajalingam, KM Coyle, SE Arthur… - Blood, The Journal …, 2020 - ashpublications.org
Mantle cell lymphoma (MCL) is an uncommon B-cell non-Hodgkin lymphoma (NHL) that is
incurable with standard therapies. The genetic drivers of this cancer have not been firmly …

Genomic landscape and prognostic analysis of mantle cell lymphoma

P Yang, W Zhang, J Wang, Y Liu, R An, H Jing - Cancer gene therapy, 2018 - nature.com
To gain insight into the molecular pathogenesis of patients with mantle cell lymphoma
(MCL), next-generation whole-exome sequencing of 16 MCL patients was performed. We …

Molecular biology of mantle cell lymphoma: from profiling studies to new therapeutic strategies

A Obrador-Hevia, SF de Mattos, P Villalonga… - Blood reviews, 2009 - Elsevier
Mantle cell lymphoma (MCL) is a well-defined lymphoid malignancy characterized by a
rapid clinical evolution and poor response to current therapeutic protocols. The hallmark …