The occurrence and mechanisms of autophagy induced by heat stress are not well known in
lung cancer cells. Here, we have demonstrated that heat stress induces autophagy in A549 …

Objective This study aims to investigate the effects of endoplasmic reticulum stress (ERS) on
autophagy, apoptosis and chemoresistance of human small cell lung cancer (SCLC) cells …

Autophagy has a complex dual role in tumor survival or cell death owning to that is an
evolutionarily conserved catabolic mechanism and provides the cells with a sustainable …

Hypoxia which commonly exists in solid tumors, leads to cancer cells chemoresistance via
provoking adaptive responses including autophagy. Therefore, we sought to evaluate the …

Autophagy is an evolutionarily conserved process for bulk degradation of cytoplasmic
components, including large molecules and organelles. It can either help to enhance or to …

Purpose: Radiofrequency ablation (RFA) is widely accepted as a curative treatment for small
hepatocellular carcinoma (HCC). However, insufficient RFA (IRFA) can lead to rapid local …

Hyperthermia is a promising anticancer treatment used in combination with radiotherapy
and chemotherapy. Temperatures above 41.5° C are cytotoxic and hyperthermia treatments …

Autophagy is an intracellular lysosomal degradation pathway where its primary function is to
allow cells to survive under stressful conditions. Autophagy is, however, a double-edge …

Autophagy influences how cancer cells respond to nutrient deprivation and hypoxic stress,
two hallmarks of the tumor microenvironment (TME). In this study, we explored the impact of …

In our previous study, we proved that a novel Heat shock protein 90 (HSP90) inhibitor 4-(3-
(7-(diethylamino)-2-oxo-2H-chromen-3-yl)-5-phenyl-4, 5-dihydro-1H-pyrazol-1-yl) benzoic …