The human trkA cDNA was transfected into a malignant human neuroblastoma (NB) cell line
(HTLA230) to investigate its role in NB growth and differentiation. This cell line lacks …

Functional nerve growth factor (NGF) responsiveness was investigated in human
neuroblastoma (NB) cell lines in vitro and retinoic acid (RA) was found to transcriptionally …

Human neuroblastoma cell lines frequently express the TRK-A proto-oncogene and bind
nerve growth factor (NGF) but do not differentiate when exposed to NGF. Transient …

We examined events associated with neuronal differentiation of neuroblastoma cell line SH-
SY5Y. Treatment with nerve growth factor (NGF) and aphidicolin, an inhibitor of DNA …

The induction of growth inhibition and differentiation of a glioma cell line by transfection of trk
A cDNA was examined, and production of endogenous nerve growth factor (NGF) also was …

Activation of the neurotrophin receptor TrkA by its ligand nerve growth factor (NGF) initiates
a cascade of signaling events leading to neuronal differentiation in vitro and might play an …

We stably expressed the nerve growth factor receptor trkA or a truncated trkA lacking the
kinase domain (trkAΔ) in a highly tumorigenic rat glioma cell line, C6. Survival of rats with …

The trkA proto-oncogene encodes a high-affinity NGF receptor that is essential for the
survival, differentiation and maintenance of many neural and non-neural cell types. Altered …

There is considerable interest in the role of the TRK family of neuotrophin receptors in
regulating growth and differentiation in normal and neoplastic nerve cells. A neuroblastoma …

Background. Neuroblastomas display a spectrum of morphologic and cytologic features of
neural cells, and the prognosis of patients with these tumors varies widely. Expression of trk …