NMJ-morph reveals principal components of synaptic morphology influencing structure–function relationships at the neuromuscular junction

RA Jones, CD Reich, KN Dissanayake… - Open …, 2016 - royalsocietypublishing.org
The ability to form synapses is one of the fundamental properties required by the
mammalian nervous system to generate network connectivity. Structural and functional …

Presynaptic to postsynaptic relationships of the neuromuscular junction are held constant across age and muscle fiber type

MR Deschenes, TE Hurst, AE Ramser… - Developmental …, 2013 - Wiley Online Library
The neuromuscular junction (NMJ) displays considerable morphological plasticity as a result
of differences in activity level, as well as aging. This is true of both presynaptic and …

Comparative anatomy of the mammalian neuromuscular junction

I Boehm, A Alhindi, AS Leite, C Logie… - Journal of …, 2020 - Wiley Online Library
The neuromuscular junction (NMJ)—a synapse formed between lower motor neuron and
skeletal muscle fibre—represents a major focus of both basic neuroscience research and …

Morphological variability is greater at developing than mature mouse neuromuscular junctions

AM Mech, AL Brown, G Schiavo… - Journal of Anatomy, 2020 - Wiley Online Library
The neuromuscular junction (NMJ) is the highly specialised peripheral synapse formed
between lower motor neuron terminals and muscle fibres. Post‐synaptic acetylcholine …

Cellular and molecular anatomy of the human neuromuscular junction

RA Jones, C Harrison, SL Eaton, ML Hurtado… - Cell reports, 2017 - cell.com
The neuromuscular junction (NMJ) plays a fundamental role in transferring information from
lower motor neuron to skeletal muscle to generate movement. It is also an experimentally …

Pre-and postsynaptic changes in the neuromuscular junction in dystrophic mice

SJP Pratt, AP Valencia, GK Le, SB Shah… - Frontiers in …, 2015 - frontiersin.org
Duchenne muscular dystrophy (DMD) is a devastating neuromuscular disease in which
weakness, increased susceptibility to muscle injury, and inadequate repair appear to …

Effects of exercise training on neuromuscular junction morphology and pre-to post-synaptic coupling in young and aged rats

MR Deschenes, KA Kressin, RN Garratt, CM Leathrum… - Neuroscience, 2016 - Elsevier
The objective of this study was to determine whether pre-to post-synaptic coupling of the
neuromuscular junction (NMJ) could be maintained in the face of significant morphological …

Mechanisms controlling neuromuscular junction stability

E Bloch-Gallego - Cellular and molecular life sciences, 2015 - Springer
The neuromuscular junction (NMJ) is the synaptic connection between motor neurons and
muscle fibers. It is involved in crucial processes such as body movements and breathing. Its …

Toward building the neuromuscular junction: in vitro models to study synaptogenesis and neurodegeneration

A Natarajan, A Sethumadhavan, UM Krishnan - ACS omega, 2019 - ACS Publications
The neuromuscular junction (NMJ) is a unique, specialized chemical synapse that plays a
crucial role in transmitting and amplifying information from spinal motor neurons to skeletal …

Dissecting the extracellular complexity of neuromuscular junction organizers

SR Guarino, A Canciani, F Forneris - Frontiers in molecular …, 2020 - frontiersin.org
Synapse formation is a very elaborate process dependent upon accurate coordination of pre
and post-synaptic specialization, requiring multiple steps and a variety of receptors and …