Unconventional GABA release: mechanisms and function

U Koch, AK Magnusson - Current opinion in neurobiology, 2009 - Elsevier
GABA is the main inhibitory neurotransmitter in the mammalian brain, and perturbed GABA
signalling is the underlying cause of many neurological and psychiatric disorders. Synaptic …

GABA, a forgotten gliotransmitter

MC Angulo, K Le Meur, AS Kozlov, S Charpak… - Progress in …, 2008 - Elsevier
The amino acid γ-aminobutiric acid (GABA) is a major inhibitory transmitter in the vertebrate
central nervous system (CNS) where it can be released by neurons and by glial cells …

Variations on an inhibitory theme: phasic and tonic activation of GABAA receptors

M Farrant, Z Nusser - Nature Reviews Neuroscience, 2005 - nature.com
The proper functioning of the adult mammalian brain relies on the orchestrated regulation of
neural activity by a diverse population of GABA (γ-aminobutyric acid)-releasing neurons …

[PDF][PDF] Pharmacology of the GABAA receptor

D Berezhnoy, MC Gravielle… - Handbook of contemporary …, 2007 - researchgate.net
Although the human central nervous system (CNS) is undoubtedly a marvel of
implementation of cellular systems, composed of roughly 1013 neurons each making …

GABA as a rising gliotransmitter

BE Yoon, CJ Lee - Frontiers in neural circuits, 2014 - frontiersin.org
Gamma-amino butyric acid (GABA) is the major inhibitory neurotransmitter that is known to
be synthesized and released from GABAergic neurons in the brain. However, recent studies …

GABA release from astrocytes in health and disease

W Kilb, S Kirischuk - International Journal of Molecular Sciences, 2022 - mdpi.com
Astrocytes are the most abundant glial cells in the central nervous system (CNS) mediating a
variety of homeostatic functions, such as spatial K+ buffering or neurotransmitter reuptake. In …

[图书][B] GABA: receptors, transporters and metabolism

C Tanaka, NG Bowery - 1996 - books.google.com
Highlighting the current developments and future directions in GABA research, the ambitious
aim of this topical volume is to cover GABA from the molecular mechanisms of its …

Extrasynaptic GABAA receptors: form, pharmacology, and function

D Belelli, NL Harrison, J Maguire… - Journal of …, 2009 - Soc Neuroscience
GABA is the principal inhibitory neurotransmitter in the CNS and acts via GABAA and
GABAB receptors. Recently, a novel form of GABAA receptor-mediated inhibition, termed …

GABA tone regulation and its cognitive functions in the brain

W Koh, H Kwak, E Cheong, CJ Lee - Nature Reviews Neuroscience, 2023 - nature.com
Abstract γ-Aminobutyric acid (GABA) is the major inhibitory neurotransmitter released at
GABAergic synapses, mediating fast-acting phasic inhibition. Emerging lines of evidence …

GABA acts as a ligand chaperone in the early secretory pathway to promote cell surface expression of GABAA receptors

RS Eshaq, LD Stahl, R Stone II, SS Smith… - Brain research, 2010 - Elsevier
GABA (γ-aminobutyric acid) is the primary inhibitory neurotransmitter in brain. The fast
inhibitory effect of GABA is mediated through the GABAA receptor, a postsynaptic ligand …