Mucosal administration of a live attenuated recombinant COVID-19 vaccine protects nonhuman primates from SARS-CoV-2

MF Tioni, R Jordan, AS Pena, A Garg, D Wu, SI Phan… - npj Vaccines, 2022 - nature.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the causative agent of
the COVID-19 global pandemic. SARS-CoV-2 is an enveloped RNA virus that relies on its …

Operation nasal vaccine—lightning speed to counter COVID-19

EJ Topol, A Iwasaki - Science immunology, 2022 - science.org
Operation Nasal Vaccine—Lightning speed to counter COVID-19 | Science Immunology news
careers commentary Journals Science Science brought to you byGoogle Indexer Log in science …

Safety and efficacy of the intranasal spray SARS-CoV-2 vaccine dNS1-RBD: a multicentre, randomised, double-blind, placebo-controlled, phase 3 trial

F Zhu, S Huang, X Liu, Q Chen, C Zhuang… - The Lancet …, 2023 - thelancet.com
Background The live-attenuated influenza virus vector-based intranasal SARS-CoV-2
vaccine (dNS1-RBD, Pneucolin; Beijing Wantai Biological Pharmacy Enterprise, Beijing …

[HTML][HTML] An intranasal vaccine durably protects against SARS-CoV-2 variants in mice

AO Hassan, S Shrihari, MJ Gorman, B Ying, D Yuan… - Cell reports, 2021 - cell.com
SARS-CoV-2 variants that attenuate antibody neutralization could jeopardize vaccine
efficacy. We recently reported the protective activity of an intranasally administered spike …

[HTML][HTML] A live attenuated virus-based intranasal COVID-19 vaccine provides rapid, prolonged, and broad protection against SARS-CoV-2

J Chen, P Wang, L Yuan, L Zhang, L Zhang, H Zhao… - Science bulletin, 2022 - Elsevier
Remarkable progress has been made in developing intramuscular vaccines against severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2); however, they are limited with …

[HTML][HTML] Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models

MW Ku, M Bourgine, P Authié, J Lopez, K Nemirov… - Cell host & …, 2021 - cell.com
To develop a vaccine candidate against coronavirus disease 2019 (COVID-19), we
generated a lentiviral vector (LV) eliciting neutralizing antibodies against the Spike …

Prospects for mucosal vaccine: shutting the door on SARS-CoV-2

R Mudgal, S Nehul, S Tomar - Human vaccines & …, 2020 - Taylor & Francis
The sudden emergence of a highly transmissible and pathogenic coronavirus SARS-CoV-2
in December 2019 from China and its rapid global spread has posed an international health …

Intranasal administration of a recombinant RBD vaccine induces long-term immunity against Omicron-included SARS-CoV-2 variants

H Lei, A Alu, J Yang, W Ren, C He, T Lan… - … and Targeted Therapy, 2022 - nature.com
The outbreak of coronavirus disease 2019 (COVID-19) has posed great threats to global
health and economy. Several effective vaccines are available now, but additional booster …

[HTML][HTML] A single-dose intranasal ChAd vaccine protects upper and lower respiratory tracts against SARS-CoV-2

AO Hassan, NM Kafai, IP Dmitriev, JM Fox, BK Smith… - Cell, 2020 - cell.com
The coronavirus disease 2019 pandemic has made deployment of an effective vaccine a
global health priority. We evaluated the protective activity of a chimpanzee adenovirus …

Intranasal booster using an Omicron vaccine confers broad mucosal and systemic immunity against SARS-CoV-2 variants

Q Wang, C Yang, L Yin, J Sun, W Wang, H Li… - … and Targeted Therapy, 2023 - nature.com
The highly contagious SARS-CoV-2 Omicron subvariants severely attenuated the
effectiveness of currently licensed SARS-CoV-2 vaccines based on ancestral strains …