Major advances in our understanding of cystic fibrosis (CF) lung disease and its treatment
have materialized over the last decades. Targeting therapies to the major pathophysiologic …

Clinical outcomes and management of cystic fibrosis (CF) have undergone startling and
dramatic advances in the last two decades. These improvements can be linked to the …

Although cystic fibrosis (CF) remains a life-limiting disease, we have witnessed major
advances in the care and clinical outcome of persons with CF (1). Animal models are …

Cystic fibrosis (CF) is a complex, hereditary disease involving several organ systems (1). CF
is caused by mutations in the gene that codes for the CF transmembrane conductance …

Although cystic fibrosis (CF) continues to be the most common life-shortening genetic
disease in whites, median predicted life expectancy has reached an all-time high in the CF …

Since the discovery of the gene encoding the cystic fibrosis transmembrane regulator
protein (CFTR) in 1989, rapid expansion in our understanding of the basic defect has …

The clinical face of cystic fibrosis (CF) has significantly changed over the 25 years since its
basic genetic defect was discovered (1). Increasing numbers of patients are diagnosed at …

Cystic fibrosis (CF) is a chronic condition involving several organ systems that results in life-
long morbidity and premature mortality (1). CF is caused by abnormalities in the gene that …

Less than a century ago, children with cystic fibrosis (CF) could not be distinguished from a
multitude of malnourished children with chronic wet cough and respiratory infection from …

Update on pathogenesis of cystic fibrosis lung disease : Current Opinion in Pulmonary
Medicine Update on pathogenesis of cystic fibrosis lung disease : Current Opinion in …