The relationship of exposure dose and tissue concentration of parent chemical and
metabolites is a critical issue in cases where toxicity may be mediated by a metabolite or by …

The relationship of exposure and tissue concentration of parent chemical and metabolites
over prolonged exposure is a critical issue for chronic toxicities mediated by metabolite (s) …

Exposure to the human carcinogen inorganic arsenic (iAs) occurs daily. However, the
disposition of arsenic after repeated exposure is not well known. This study examined the …

Recent studies have suggested that polymorphisms in the methylation of inorganic arsenic
(iAs) exist in animals and humans. Methylation of iAs is an important step in the elimination …

Abstract Dose-Dependent Disposition of Sodium Arsenate in Mice Following Acute Oral
Exposure. Hughes, MF, Menache, M., and Thompson, DJ (1994). Fundam. Appl. Toxicol. 22 …

Humans are exposed to arsenic and their organic derivatives, which are widely distributed in
the environment, via food, water, and to a lesser extent, via air. Following uptake, inorganic …

Arsenite (AsIII) is eliminated via excretion and methylation. Monomethylarsonous acid
(MMAsIII) is a super toxic metabolite of AsIII, while dimethylarsinic acid produced in the next …

Arsenic is a ubiquitous contaminant, with typical dietary intake below 1 μg/kg bw/d and
drinking water exposures up to 50 μg/kg bw/d. Arsenic exposures are associated with …

Although it has been known for decades that humans and many other species convert
inorganic arsenic to mono-and dimethylated metabolites, relatively little attention has been …

The understanding of the biomethylation process of arsenic is essential to uncover the
mechanisms of arsenic toxicity. This work analyzes the time course of arsenic species in the …