Circular RNA translation, a path to hidden proteome

T Sinha, C Panigrahi, D Das… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Functional proteins in the cell are translated from the messenger RNA (mRNA) molecules,
constituting less than 5% of the cellular transcriptome. The majority of the RNA molecules in …

[HTML][HTML] Translation and functional roles of circular RNAs in human cancer

M Lei, G Zheng, Q Ning, J Zheng, D Dong - Molecular cancer, 2020 - Springer
Circular RNAs (circRNAs) are a new class of non-coding RNAs formed by covalently closed
loops through backsplicing. Recent methodologies have enabled in-depth characterization …

[HTML][HTML] Expanding uncapped translation and emerging function of circular RNA in carcinomas and noncarcinomas

Y Wang, C Wu, Y Du, Z Li, M Li, P Hou, Z Shen, S Chu… - Molecular cancer, 2022 - Springer
Circular RNAs (circRNAs) are classified as noncoding RNAs because they are devoid of a
5'end cap and a 3'end poly (A) tail necessary for cap-dependent translation. However …

Emerging roles and context of circular RNAs

AC Panda, I Grammatikakis, R Munk… - Wiley …, 2017 - Wiley Online Library
Circular RNAs (circRNAs) represent a large class of noncoding RNAs (ncRNAs) that have
recently emerged as regulators of gene expression. They have been shown to suppress …

The emerging landscape of circular RNA in life processes

S Qu, Y Zhong, R Shang, X Zhang, W Song, J Kjems… - RNA biology, 2017 - Taylor & Francis
abstract Circular RNAs (circRNAs) are a novel class of non-coding RNA that assumes a
covalently closed continuous conformation. CircRNAs were previously thought to be the …

Circular RNA translation: novel protein isoforms and clinical significance

S Wen, J Qadir, BB Yang - Trends in molecular medicine, 2022 - cell.com
In recent years, significant attention has focused on circular RNA (circRNA) translation to
determine its clinical significance. Cap-independent translation of circRNAs driven by an …

[HTML][HTML] Emerging role of circular RNA–protein interactions

A Das, T Sinha, S Shyamal, AC Panda - Non-coding RNA, 2021 - mdpi.com
Circular RNAs (circRNAs) are emerging as novel regulators of gene expression in various
biological processes. CircRNAs regulate gene expression by interacting with cellular …

CircPro: an integrated tool for the identification of circRNAs with protein-coding potential

X Meng, Q Chen, P Zhang, M Chen - Bioinformatics, 2017 - academic.oup.com
Circular RNAs (circRNAs), a novel class of endogenous RNAs, are widespread in eukaryotic
cells. Emerging roles in diverse biological processes suggest that circRNA is a promising …

Circular RNA in disease: Basic properties and biomedical relevance

X Chen, M Zhou, L Yant… - Wiley Interdisciplinary …, 2022 - Wiley Online Library
Circular RNAs (circRNAs) represent a class of covalently closed RNA molecules with great
diversity in molecular features, functions, and regulatory mechanisms. Emerging advances …

Intriguing circles: conflicts and controversies in circular RNA research

HM Li, XL Ma, HG Li - Wiley Interdisciplinary Reviews: RNA, 2019 - Wiley Online Library
Circular RNAs (circRNAs) are covalently closed RNA circles without a 5′ cap or 3′ tail.
Since the landmark discovery of ciRS‐7/CDR1as functioning as a miR‐7 sponge in 2013 …