Host factors restricting the transmission of respiratory viruses are poorly characterized. We
analyzed the contribution of type I and type III interferon (IFN) using a mouse model in which …

The type I alpha/beta interferons (IFN-α/β) are known to play an important role in host
defense against influenza A virus infection, but we have now discovered that the recently …

Virus-infected cells secrete a broad range of interferon (IFN) subtypes which in turn trigger
the synthesis of antiviral factors that confer host resistance. IFN-α, IFN-β and other type I …

Virus-infected cells secrete a broad range of interferons (IFN) which confer resistance to yet
uninfected cells by triggering the synthesis of antiviral factors. The relative contributions of …

IFNs protect from virus infection by inducing an antiviral state and by modulating the immune
response. Using mice deficient in multiple aspects of IFN signaling, we found that type I and …

Lambda interferons (IFNλs) or type III IFNs share homology, expression patterns, signaling
cascades, and antiviral functions with type I IFNs. This has complicated the unwinding of …

Interferons (IFNs) are a group of cytokines with a well-established antiviral function. They
can be induced by viral infection, are secreted and bind to specific receptors on the same or …

Viruses suppress host responses to increase infection, and understanding these
mechanisms has provided insights into cellular signaling and led to novel therapies. Many …

Type I interferons (IFNs) are produced early upon virus infection and signal through the
alpha/beta interferon (IFN-α/β) receptor (IFNAR) to induce genes that encode proteins …

Type III interferon (IFN-λ) was initially thought to have functions similar to those of the type I
interferons (IFN-α and IFN-β). New findings have indicated, however, that IFN-λ has a non …