Two natural products databases, the marine natural products database (MNPD) and the
traditional Chinese medicines database (TCMD), were used to find novel structures of potent …

A structure‐based in silico virtual drug discovery procedure was assessed with severe acute
respiratory syndrome coronavirus main protease serving as a case study. First, potential …

Pharmacophore-based virtual screening is an effective, inexpensive and fast approach to
discovering useful starting points for drug discovery. In this study, we developed a …

Pharmacophore modeling can provide valuable insight into ligand− receptor interactions. It
can also be used in 3D (dimensional) database searching for potentially finding biologically …

Abstract The 3C-like protease (3CL pro) of severe acute respiratory syndrome associated
coronavirus (SARS-CoV) is vital for SARS-CoV replication and is a promising drug target …

The SARS coronavirus 3C-like proteinase is considered as a potential drug design target for
the treatment of severe acute respiratory syndrome (SARS). Owing to the lack of available …

The severe acute respiratory syndrome-associated coronavirus (SARS-CoV) 3C-like
protease (3CLpro or Mpro) is an attractive target for the development of anti-SARS drugs …

Synthesis and evaluation of new scaffold phenylisoserine derivatives connected with the
essential functional groups against SARS CoV 3CL protease are described. The …

In order to find effective peptide inhibitors against SARS CoV Mpro, an analysis was
performed for 11 oligopeptides that can be cleaved by the SARS coronavirus main protease …

A series of 2-(benzylthio)-6-oxo-4-phenyl-1, 6-dihydropyrimidine as SARS-CoV 3CL
protease inhibitors were developed and their potency was evaluated by in vitro protease …