[HTML][HTML] COVID-19: towards understanding of pathogenesis

W Cao, T Li - Cell research, 2020 - nature.com
The pandemic of coronavirus disease 2019 (COVID-19) is spreading rapidly. Although the
cause was quickly identified as a new coronavirus named SARS-CoV-2, our knowledge of …

Underlying vulnerabilities to the cytokine storm and adverse COVID-19 outcomes in the aging immune system

LS Nidadavolu, JD Walston - The Journals of Gerontology …, 2021 - academic.oup.com
Older adults are far more vulnerable to adverse health outcomes and mortality after
contracting COVID-19. There are likely multiple age-related biological, clinical, and …

[HTML][HTML] Age-induced NLRP3 inflammasome over-activation increases lethality of SARS-CoV-2 pneumonia in elderly patients

PC Lara, D Macías-Verde, J Burgos-Burgos - Aging and disease, 2020 - ncbi.nlm.nih.gov
Age is one of the most important prognostic factors associated to lethality in SARS-CoV-2
infection. In multivariate analysis, advanced age was an independent risk factor for death …

[HTML][HTML] Cytokine profiles associated with acute COVID-19 and long COVID-19 syndrome

MAF Queiroz, PFM Neves, SS Lima… - Frontiers in cellular …, 2022 - frontiersin.org
The duration and severity of COVID-19 are related to age, comorbidities, and cytokine
synthesis. This study evaluated the impact of these factors on patients with clinical …

[HTML][HTML] Role of senescence in the chronic health consequences of COVID-19

EOW Gerdes, G Vanichkachorn, BP Verdoorn… - Translational …, 2022 - Elsevier
While the full impact of COVID-19 is not yet clear, early studies have indicated that upwards
of 10% of patients experience COVID-19 symptoms longer than 3 weeks, known as Long …

[HTML][HTML] Aging, immunity, and COVID-19: how age influences the host immune response to coronavirus infections?

V Bajaj, N Gadi, AP Spihlman, SC Wu, CH Choi… - Frontiers in …, 2021 - frontiersin.org
The novel coronavirus severe acute respiratory syndrome coronavirus 2 causing the
Coronavirus disease (COVID-19) pandemic has ravaged the world with over 72 million total …

Emerging aspects of cytokine storm in COVID-19: The role of proinflammatory cytokines and therapeutic prospects

R Dharra, AK Sharma, S Datta - Cytokine, 2023 - Elsevier
COVID-19 has claimed millions of lives during the last 3 years since initial cases were
reported in Wuhan, China, in 2019. Patients with COVID-19 suffer from severe pneumonia …

COVID-19 pathophysiology: A review

K Yuki, M Fujiogi, S Koutsogiannaki - Clinical immunology, 2020 - Elsevier
In December 2019, a novel coronavirus, now named as SARS-CoV-2, caused a series of
acute atypical respiratory diseases in Wuhan, Hubei Province, China. The disease caused …

[HTML][HTML] High levels of circulating IL-8 and soluble IL-2R are associated with prolonged illness in patients with severe COVID-19

A Ma, L Zhang, X Ye, J Chen, J Yu, L Zhuang… - Frontiers in …, 2021 - frontiersin.org
Objectives The coordinated immune response of the host is the key of the successful combat
of the body against SARS-CoV-2 infection and is decisive for the development and …

[HTML][HTML] Long COVID: A proposed hypothesis-driven model of viral persistence for the pathophysiology of the syndrome

D Buonsenso, M Piazza, AL Boner… - Allergy and Asthma …, 2022 - ncbi.nlm.nih.gov
Background: Long COVID (coronavirus disease 2019) syndrome includes a group of
patients who, after infection with severe acute respiratory syndrome coronavirus 2 (SARS …