Plasmid Costs Explain Plasmid Maintenance, Irrespective of the Nature of Compensatory Mutations

JS Rebelo, CPF Domingues, F Dionisio - Antibiotics, 2023 - mdpi.com
Conjugative plasmids often carry virulence and antibiotic-resistant genes. Therefore,
understanding the behavior of these extra-chromosomal DNA elements gives insights into …

Plasmid interactions can improve plasmid persistence in bacterial populations

JA Gama, R Zilhão, F Dionisio - Frontiers in Microbiology, 2020 - frontiersin.org
It is difficult to understand plasmid maintenance in the absence of selection and theoretical
models predict the conditions for plasmid persistence to be limited. Plasmid-associated …

Mobile compensatory mutations promote plasmid survival

M Zwanzig, E Harrison, MA Brockhurst, JPJ Hall… - Msystems, 2019 - Am Soc Microbiol
The global dissemination of plasmids encoding antibiotic resistance represents an urgent
issue for human health and society. While the fitness costs for host cells associated with …

Assessing the role of bacterial innate and adaptive immunity as barriers to conjugative plasmids

B Siedentop, C Losa Mediavilla… - Molecular Biology …, 2024 - academic.oup.com
Plasmids are ubiquitous mobile genetic elements, that can be either costly or beneficial for
their bacterial host. In response to constant viral threat, bacteria have evolved various …

Plasmids increase the competitive ability of plasmid-bearing cells even when transconjugants are poor donors, as shown by computer simulations

JS Rebelo, CPF Domingues, T Nogueira, F Dionisio - Microorganisms, 2023 - mdpi.com
Bacterial cells often suffer a fitness cost after conjugative plasmids' entry because these cells
replicate slower than plasmid-free cells. Compensatory mutations may appear after tens of …

Interspecific competition can drive the loss of conjugative plasmids from a focal species in a microbial community

D Walker-Sünderhauf, U Klümper, WH Gaze… - bioRxiv, 2022 - biorxiv.org
Plasmids are key disseminators of antimicrobial resistance genes and virulence factors, and
it is therefore critical to predict and reduce plasmid spread within microbial communities. The …

Conjugative plasmids enable the maintenance of low cost non-transmissible plasmids

M Werisch, U Berger, TU Berendonk - Plasmid, 2017 - Elsevier
Some plasmids can be transferred by conjugation to other bacterial hosts. But almost half of
the plasmids are non-transmissible. These plasmid types can only be transmitted to the …

Harmful behaviour through plasmid transfer: a successful evolutionary strategy of bacteria harbouring conjugative plasmids

CPF Domingues, JS Rebelo… - … of the Royal …, 2022 - royalsocietypublishing.org
Conjugative plasmids are extrachromosomal mobile genetic elements pervasive among
bacteria. Plasmids' acquisition often lowers cells' growth rate, so their ubiquity has been a …

Conjugation dynamics depend on both the plasmid acquisition cost and the fitness cost

H Prensky, A Gomez‐Simmonds… - Molecular systems …, 2021 - embopress.org
Plasmid conjugation is a major mechanism responsible for the spread of antibiotic
resistance. Plasmid fitness costs are known to impact long‐term growth dynamics of …

Plasmid viability depends on the ecological setting of hosts within a multiplasmid community

C Given, R Penttinen, M Jalasvuori - Microbiology Spectrum, 2022 - Am Soc Microbiol
Plasmids are extrachromosomal genetic elements, some of which disperse horizontally
between different strains and species of bacteria. They are a major factor in the …