THE IDENTIFICATION OF BRCA1 and BRCA21, 2 marked the first time that highly penetrant
cancer predisposition genes were linked to the development of a common cancer, raising …

PURPOSE: To review the preclinical and clinical studies relevant to the prognosis and
prognostic associations of BRCA1-and BRCA2-associated breast carcinomas, with an …

Purpose To compare breast cancer prognosis in BRCA1 and BRCA2 mutation carriers with
that in patients with sporadic disease. Patients and Methods An international population …

Hereditary genetic mutations cause about 5% of breast cancers. In these cases, the
hereditary predisposition may be so strong that nongenetic risk factors have only a minor …

BACKGROUND There is a clear and growing need for data regarding BRCA1 and BRCA2
mutation frequencies among breast carcinoma cases not specifically ascertained on the …

Purpose Mutations in the BRCA1 and BRCA2 genes confer greater risk of developing breast
cancer. We determined whether tumor pathologic features and clinical features differ in …

Breast cancers arising in women with and without a germline mutation in the BRCA1 or
BRCA2 gene display different histological features, which suggests unique mechanisms of …

Breast cancer risk for noncarriers of family-specific BRCA1 and BRCA2 mutations: more
trouble with phenocopies. - Abstract - Europe PMC Sign in | Create an account https://orcid.org …

Background Familial breast cancer accounts for 20–30% of all breast cancer cases.
Mutations in the BRCA1 and BRCA2 genes account for the majority of high risk families with …

Breast cancers (BCs) arising in carriers of germline BRCA1 and BRCA2 pathogenic variants
(PV) have long been considered as indistinguishable biological and clinical entities …