Highlights•Human CD1-autoreactive T cells are common and can mediate autoimmunity.•T
cell receptors can bind directly to CD1 without contacting bound lipid.•Lipids can hide buried …

The hallmark function of αβ T cell antigen receptors (TCRs) involves the highly specific co-
recognition of a major histocompatibility complex molecule and its carried peptide. However …

Lipid‐specific T cells comprise a group of T cells that recognize lipids bound to the MHC
class I‐like CD1 molecules. There are four isoforms of CD1 that are expressed at the surface …

The CD1 and MHC systems are specialized for lipid and peptide display, respectively. Here,
we review evidence showing how cellular CD1a, CD1b, CD1c, and CD1d proteins capture …

CD1 proteins have been conserved throughout mammalian evolution and function to
present lipid antigens to T cells. Crystal structures of CD1‐lipid complexes show that CD1 …

The recognition of lipid antigens by T cells is a complex and fascinating phenomenon. The
MHC‐like molecules of the CD1 family have evolved to present a wide variety of both self …

A central paradigm in αβ T cell–mediated immunity is the simultaneous co-recognition of
antigens and antigen-presenting molecules by the αβ T cell antigen receptor (TCR). CD1a …

Over two decades ago, it was discovered that the human T‐cell repertoire contains T cells
that do not recognize peptide antigens in the context of MHC molecules but instead respond …

T cell responses are generally regarded as specific for protein‐derived peptide antigens.
This is based on the molecular paradigm dictated by the T cell receptor (TCR) recognition of …

The Easy Virtue of CD1c: Immunity Skip to Main Content Advertisement Immunity This journal
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