Cellular senescence has become a subject of great interest within the ageing research field
over the last 60 years, from the first observation in vitro by Leonard Hayflick and Paul …

Neurodegenerative diseases, such as Alzheimer's and Parkinson's, are characterized by
several pathological features, including selective neuronal loss, aggregation of specific …

Cellular senescence (CS) is one of hallmarks of aging and accumulation of senescent cells
(SCs) with age contributes to tissue or organismal aging, as well as the pathophysiologies of …

The adult central nervous system (CNS) contains resident stem cells within specific niches
that maintain a self-renewal and proliferative capacity to generate new neurons, astrocytes …

Multiple sclerosis (MS) is a chronic and often progressive, demyelinating disease of the
central nervous system (CNS) white and gray matter and the single most common cause of …

Cellular senescence is a state of stable cell cycle arrest associated with macromolecular
alterations and secretion of proinflammatory cytokines and molecules. From their initial …

Senescence is a cellular stress response that involves prolonged cell survival, a quasi-
irreversible proliferative arrest and a modification of the transcriptome that sometimes …

Globally, 50 million people live with dementia, with Alzheimer disease (AD) being
responsible for two-thirds of the total cases. As ageing is the main risk factor for dementia …

In 1960, Rita Levi-Montalcini and Barbara Booker made an observation that transformed
neuroscience: as neurons mature, they become apoptosis resistant. The following year …

There is tremendous interest in the development of drugs that target senescent cells
('senolytic'drugs) to treat a range of age-related morbidities. However, studies in mice that …