Chronic aging represents the leading risk factor for the vast majority of age-related diseases,
which together contribute to increased morbidities and elevated mortalities in late life …

Aging is associated with cell senescence and is the major risk factor for AD. We
characterized premature cell senescence in postmortem brains from non-diseased controls …

Current antiaging strategies focusing on druggable targets have met with relatively limited
success to date. Replacement of cells, tissues, and organs could provide an alternative …

Cellular senescence is a state of stable cell cycle arrest that is known to be elicited in
response to different stresses or forms of damage. Senescence limits the replication of old …

Aging has a profound and devastating effect on the brain. Old age is accompanied by
declining cognitive function and enhanced risk of brain diseases, including cancer and …

Organismal ageing is a complex process driving progressive impairment of functionality and
regenerative potential of tissues. Cellular senescence is a state of stable cell cycle arrest …

The increasing life expectancy of the world population has become an economic and global
public health problem. Increased life expectancy tracks with a higher incidence of multiple …

Cellular senescence, a process that imposes permanent proliferative arrest on cells in
response to various stressors, has emerged as a potentially important contributor to aging …

Aging is a natural but relentless process of physiological decline, leading to physical frailty,
reduced ability to respond to physical stresses (resilience) and, ultimately, organismal death …

Cellular senescence has emerged as a fundamental biological mechanism underpinning
the ageing process and has been implicated in the pathogenesis of an increasing number of …