Background: As the largest organ in the human body, the skin is continuously exposed to
intrinsic and extrinsic stimuli that impact its functionality and morphology with aging. Skin …

Aging leads to a high burden on society, both medically and economically. Cellular
senescence plays an essential role in the initiation of aging and age-related diseases …

Physical function declines in old age, portending disability, increased health expenditures,
and mortality. Cellular senescence, leading to tissue dysfunction, may contribute to these …

Cellular senescence is a cell fate involving cell cycle arrest, resistance against apoptosis,
and the development of a secretome that can be pro-inflammatory. In aging and obesity …

The adult mammalian brain contains distinct neurogenic niches harboring populations of
neural stem cells (NSCs) with the capacity to sustain the generation of specific subtypes of …

Healthy aging is the art of balancing a delicate scale. On one side of the scale, there are the
factors that make life difficult with aging, and on the other side are the products of human …

Cellular senescence is a hallmark of aging defined by stable exit from the cell cycle in
response to cellular damage and stress. Senescent cells (SnCs) can develop a …

Recent improvements in cancer treatment have increased the lifespan of pediatric and adult
cancer survivors. However, cancer treatments accelerate aging in survivors, which manifests …

The term cellular senescence was introduced more than five decades ago to describe the
state of growth arrest observed in aging cells. Since this initial discovery, the phenotypes …

Due to their postmitotic status, the potential for neurons to undergo senescence has
historically received little attention. This lack of attention has extended to some non …