Previous research suggests that exposure to early life stress (ELS) affects the structural
integrity of the uncinate fasciculus (UF), a frontolimbic white matter tract that undergoes …

The experience of child maltreatment is a significant risk factor for the development of later
internalizing disorders such as depression and anxiety. This risk is particularly heightened …

Childhood adversity is associated with a wide range of negative behavioral and
neurodevelopmental consequences. However, individuals vary substantially in their …

Early life stress (ELS) is a risk factor for the development of depression in adolescence; the
mediating neurobiological mechanisms, however, are unknown. In this study, we examined …

Adolescence is often characterized by sleep disturbances that can affect the development of
white matter tracts implicated in affective and cognitive regulation, including the cingulate …

Background Anxious temperament (AT) is an early-life heritable trait that predisposes
individuals to develop anxiety and depressive disorders. Our previous work in …

Preadolescence is a period of increased vulnerability for anxiety, especially among Latina
girls. Reduced microstructure (fractional anisotropy; FA) of white matter tracts between limbic …

Early life stress (ELS) is associated with increased risk for internalizing disorders and
variations in gray matter development. It is unclear, however, whether ELS affects normative …

Objective: Anxiety disorders are common, can result in lifelong suffering, and frequently
begin before adolescence. Evidence from adults suggests that altered prefrontal-limbic …

The uncinate fasciculus (UF) is a long-range white matter tract that connects limbic regions
in the temporal lobe to the frontal lobe. The UF is one of the latest developing tracts, and …