Maternal inflammation and its ramifications on fetal neurodevelopment

HK Kwon, GB Choi, JR Huh - Trends in immunology, 2022 - cell.com
Exposure to heightened inflammation in pregnancy caused by infections or other
inflammatory insults has been associated with the onset of neurodevelopmental and …

Maternal immune activation, central nervous system development and behavioral phenotypes

E Minakova, BB Warner - Birth defects research, 2018 - Wiley Online Library
Maternal immune activation (MIA) refers to a maternal immune system triggered by
infectious or infectious‐like stimuli. A cascade of cytokines and immunologic alterations are …

Maternal immune activation and related factors in the risk of offspring psychiatric disorders

F Conway, AS Brown - Frontiers in psychiatry, 2019 - frontiersin.org
Maternal immune activation (MIA) at the time of gestation has been linked to increased risk
of neurodevelopmental psychiatric disorders. Animal and human models have been used to …

Increasing role of maternal immune activation in neurodevelopmental disorders

J Boulanger-Bertolus, C Pancaro… - Frontiers in behavioral …, 2018 - frontiersin.org
The earliest stages of development are critically sensitive to environmental insults. An
unfortunately timed stress on the developing brain can have dramatic consequences for the …

Maternal immune activation in mice disrupts proteostasis in the fetal brain

BT Kalish, E Kim, B Finander, EE Duffy, H Kim… - Nature …, 2021 - nature.com
Maternal infection and inflammation during pregnancy are associated with
neurodevelopmental disorders in offspring, but little is understood about the molecular …

[HTML][HTML] Translational opportunities in the prenatal immune environment: Promises and limitations of the maternal immune activation model

MD Bauman, J Van de Water - Neurobiology of disease, 2020 - Elsevier
The prenatal environment, and in particular, the maternal-fetal immune environment, has
emerged as a targeted area of research for central nervous system (CNS) diseases with …

Maternal inflammation and neurodevelopmental programming: a review of preclinical outcomes and implications for translational psychiatry

SB Gumusoglu, HE Stevens - Biological psychiatry, 2019 - Elsevier
Early disruptions to neurodevelopment are highly relevant to understanding both psychiatric
risk and underlying pathophysiology that can be targeted by new treatments. Much …

Maternal immune activation dysregulation of the fetal brain transcriptome and relevance to the pathophysiology of autism spectrum disorder

MV Lombardo, HM Moon, J Su, TD Palmer… - Molecular …, 2018 - nature.com
Maternal immune activation (MIA) via infection during pregnancy is known to increase risk
for autism spectrum disorder (ASD). However, it is unclear how MIA disrupts fetal brain gene …

Maternal immune activation in neurodevelopmental disorders

CM Solek, N Farooqi, M Verly, TK Lim… - Developmental …, 2018 - Wiley Online Library
Converging lines of evidence from basic science and clinical studies suggest a relationship
between maternal immune activation (MIA) and neurodevelopmental disorders such as …

The role of maternal immune activation in altering the neurodevelopmental trajectories of offspring: A translational review of neuroimaging studies with implications for …

E Guma, E Plitman, MM Chakravarty - Neuroscience & Biobehavioral …, 2019 - Elsevier
Exposure to maternal infection in utero increases the risk that offspring will develop
neurodevelopmental disorders such as autism spectrum disorder (ASD) and schizophrenia …