EXPANDING T-CELLS TO HIGH CELL CONCENTRATIONS IN A MICROFLUIDIC PERFUSED DEVICE
J Aranda-Hernandez, O Derevianko, P Springuel… - Cytotherapy, 2024 - Elsevier
Process Development and Manufacturing 800 Process Development and Manufacturing
STREAMLINING AND CLOSING CRITICAL STAGES OF THE AGONOX CELL THERAPY …
STREAMLINING AND CLOSING CRITICAL STAGES OF THE AGONOX CELL THERAPY …
THE VALUE OF AUTOMATED FEEDING REGIMES IN SCALABLE PRIMARY T-CELL EXPANSION
C Cejas, N Naeem, R Baxter, N Akosa, L Clarke… - Cytotherapy, 2024 - Elsevier
Background & Aim We demonstrate the positive impacts of automated feeding regimes in
improving cell culture. Cell culture in scaled-down research bioreactors takes advantage of …
improving cell culture. Cell culture in scaled-down research bioreactors takes advantage of …
STREAMLINING AND CLOSING CRITICAL STAGES OF THE AGONOX CELL THERAPY MANUFACTURING PROCESS
N Sanjuan, A Weinberg, R Montler, C Thalhofer… - Cytotherapy, 2024 - Elsevier
Background & Aim AgonOx and Providence worked with ScaleReady to enhance their
manufacturing process for an IND filing. ScaleReady proposed a streamlined approach …
manufacturing process for an IND filing. ScaleReady proposed a streamlined approach …
COMPARATIVE ANALYSIS OF T CELL EXPANSION BY BIOREACTOR TYPE: IMPACTS ON PROCESS METRICS AND CELL QUALITY
Background & Aim The device used to scale up and manufacture an immunotherapeutic
agent is a highly relevant factor in ensuring the most optimal product in terms of the time it …
agent is a highly relevant factor in ensuring the most optimal product in terms of the time it …
Mini-review: Equipment evaluation for process scalability and readiness for current Good Manufacturing Practices in cell therapy workflows
M Verbarendse, R Snyder, U Lakshmipathy - Cytotherapy, 2023 - Elsevier
Cell therapies present a promising treatment for a variety of diseases and are a rapidly
growing market. This facilitates the need for robust biomanufacturing processes that can be …
growing market. This facilitates the need for robust biomanufacturing processes that can be …
Rotea: a closed and automated instrument for efficient cell isolation, washing and conentration in cell therapy workflows
CT Dargitz, S Daoudi, S Dunn, XM du Jeu, N Ravinder - Cytotherapy, 2020 - Elsevier
Background & Aim BACKGROUND: Processing and delivering cell and gene therapy
products is of vital importance to patients and has presented numerous challenges. Rotea's …
products is of vital importance to patients and has presented numerous challenges. Rotea's …
Automated closed systems for cell manufacturing
Background & Aim As more autologous cell therapy products are coming through the FDA
approval and clinical trial pipeline, there is a need for validated cell manufacturing system …
approval and clinical trial pipeline, there is a need for validated cell manufacturing system …
Improved expansion of T cells in culture when isolated with an equipment-free, high-throughput, flow-through microfluidic module versus traditional density gradient …
Background The isolation of lymphocytes–and removal of platelets (PLTs) and red blood
cells (RBCs)–from an initial blood sample prior to culture is a key enabling step for effective …
cells (RBCs)–from an initial blood sample prior to culture is a key enabling step for effective …
[PDF][PDF] Continuous cell culture operation at 2,000-L scale
M Sherman, V Lam, M Carpio, N Hutchinson… - BioProcess …, 2016 - sartorius.com.cn
In the biopharmaceutical industry, continuous manufacturing is often cited as a method for
increasing the productivity of bioprocesses (1). Compared with batch processing, it has the …
increasing the productivity of bioprocesses (1). Compared with batch processing, it has the …
Technological developments for small-scale downstream processing of cell therapies
RL Buckler, EJ Kunkel, ML Thompson, RO Ehrhardt - Cytotherapy, 2016 - Elsevier
Despite considerable regulatory and clinical hurdles, the development and use of cell-based
therapies are gaining momentum. As more of these therapies move toward commercial …
therapies are gaining momentum. As more of these therapies move toward commercial …