Abstract Interleukin-1, an inflammatory cytokine, is considered to have diverse physiological
functions and pathological significances and play an important role in health and disease. In …

The interleukin (IL) 1 family of cytokines is noteworthy to have pleiotropic functions in
inflammation and acquired immunity. Over the last decades, several progresses have been …

Abstract Interleukin (IL)-1, first described∼ 35 years ago as a secreted product of monocytes
and neutrophils, refers to IL-1α and IL-1β, two key cytokines in the activation of innate …

Inflammation occurs after disruption of tissue homeostasis by cell stress, injury or infection
and ultimately involves the recruitment and retention of cells of hematopoietic origin, which …

Abstract The interleukin (IL)-1 family member IL-1α is a ubiquitous and pivotal pro-
inflammatory cytokine. The IL-1α precursor is constitutively present in nearly all cell types in …

Cytokines activate or inhibit immune cell behavior and are thus integral to all immune
responses. IL-1α and IL-1β are powerful apical cytokines that instigate multiple downstream …

Biochemically, interleukin-6 belongs to the class of four-helical cytokines. The cytokine can
be synthesised and secreted by many cells. It acts via a cell surface-expressed interleukin-6 …

Immunological memory was long considered a trait exclusive to cells of the adaptive
immune system. However, recent studies have shown that after activation of the innate …

Interleukin-1 (IL-1) is a central mediator of innate immunity and inflammation. The IL-1 family
includes seven ligands with agonist activity (IL-1α and IL-1β, IL-18, IL-33, IL-36α, IL-36β, IL …

Forty years after its naming, interleukin-1 (IL-1) is experiencing a renaissance brought on by
the growing understanding of its context-dependent roles and advances in the clinic. Recent …