The immune response as a double‐edged sword: The lesson learnt during the COVID‐19 pandemic

C Agrati, R Carsetti, V Bordoni, A Sacchi… - …, 2022 - Wiley Online Library
The COVID‐19 pandemic has represented an unprecedented challenge for the humanity,
and scientists around the world provided a huge effort to elucidate critical aspects in the fight …

[HTML][HTML] An impaired inflammatory and innate immune response in COVID-19

SH Park - Molecules and cells, 2021 - Elsevier
The recent appearance of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has affected millions of people around the world and caused a global pandemic of …

Prevention and treatment of COVID‐19 disease by controlled modulation of innate immunity

V Schijns, EC Lavelle - European journal of immunology, 2020 - Wiley Online Library
The recent outbreak of coronavirus disease 2019 (COVID‐19), triggered by the severe acute
respiratory syndrome coronavirus 2 (SARS‐CoV‐2) poses an enormous threat to global …

The interplay between inflammatory pathways and COVID-19: A critical review on pathogenesis and therapeutic options

S Choudhary, K Sharma, O Silakari - Microbial pathogenesis, 2021 - Elsevier
Abstract COVID-19, caused by SARS-CoV-2, emerged as the deadliest outbreak that has
now become a serious health issue to mankind. Activation of inflammatory signaling …

Immune signature of covid-19: In-depth reasons and consequences of the cytokine storm

P Niedźwiedzka-Rystwej, A Majchrzak… - International Journal of …, 2022 - mdpi.com
In the beginning of the third year of the fight against COVID-19, the virus remains at least still
one step ahead in the pandemic “war”. The key reasons are evolving lineages and …

The signal pathways and treatment of cytokine storm in COVID-19

L Yang, X Xie, Z Tu, J Fu, D Xu, Y Zhou - Signal transduction and …, 2021 - nature.com
Abstract The Coronavirus Disease 2019 (COVID-19) pandemic has become a global crisis
and is more devastating than any other previous infectious disease. It has affected a …

The SARS-CoV-2 as an instrumental trigger of autoimmunity

A Dotan, S Muller, D Kanduc, P David, G Halpert… - Autoimmunity …, 2021 - Elsevier
Autoimmunity may be generated by a variety of factors by creating a hyper-stimulated state
of the immune system. It had been established long ago that viruses are a substantial …

A review of cytokine-based pathophysiology of Long COVID symptoms

RN Low, RJ Low, A Akrami - Frontiers in Medicine, 2023 - frontiersin.org
The Long COVID/Post Acute Sequelae of COVID-19 (PASC) group includes patients with
initial mild-to-moderate symptoms during the acute phase of the illness, in whom recovery is …

COVID-19: immunology, immunopathogenesis and potential therapies

A Bhardwaj, L Sapra, C Saini, Z Azam… - International reviews …, 2022 - Taylor & Francis
Abstract The Coronavirus Disease-2019 (COVID-19) imposed public health emergency and
affected millions of people around the globe. As of January 2021, 100 million confirmed …

COVID-19 cytokine storm: The anger of inflammation

M Mahmudpour, J Roozbeh, M Keshavarz, S Farrokhi… - Cytokine, 2020 - Elsevier
Patients with COVID-19 who require ICU admission might have the cytokine storm. It is a
state of out-of-control release of a variety of inflammatory cytokines. The molecular …