Neurosteroid dehydroepiandrosterone improves active avoidance retrieval and induces antidepressant-like behavior in rats

J Samardzic, B Hencic, J Jancic, D Jadzic, M Djuric… - Neuroscience …, 2017 - Elsevier
Various studies reported beneficial effects of dehydroepiandrosterone (DHEA) and its
sulphate (DHEAS), the neurosteroids involved in various brain functions, on synaptic …

Behavioral effects of dehydroepiandrosterone in adult male rats

J Fedotova, N Sapronov - Progress in Neuro-Psychopharmacology and …, 2004 - Elsevier
It is well-documented that dehydroepiandrosterone (DHEA) exhibits various behavioral
effects in rodents, at least one of which is modulation of learning/memory processes in …

The neurosteroids DHEA and DHEAS may influence cognitive performance by altering affective state

CA Frye, EH Lacey - Physiology & behavior, 1999 - Elsevier
The effects of Dehydroepiandrosterone (DHEA) and its sulfate ester,
Dehydroepiandrosterone sulfate (DHEAS) on performance in various cognitive and affective …

The effects of DHEA, 3β-hydroxy-5α-androstane-6, 17-dione, and 7-amino-DHEA analogues on short term and long term memory in the mouse

MA Bazin, L El Kihel, M Boulouard, V Bouët, S Rault - Steroids, 2009 - Elsevier
Neurosteroids have been reported to modulate memory processes in rodents. Three
analogues of dehydroepiandrosterone (DHEA), two of them previously described (7β …

Dehydroepiandrosterone increases synaptosomal glutamate release and improves the performance in inhibitory avoidance task

FLR Lhullier, R Nicolaidis, NG Riera, F Cipriani… - Pharmacology …, 2004 - Elsevier
Dehydroepiandrosterone (DHEA) exerts multiple effects in the rodent central nervous
system (CNS), mediated through its nongenomic actions on several neurotransmitter …

The protective effect of frontal cortex dehydroepiandrosterone in anxiety and depressive models in mice

R Maayan, D Touati-Werner, E Ram, R Strous… - Pharmacology …, 2006 - Elsevier
We aimed to verify whether DHEA, a neuoroactive neurosteroid, has a protective role in
preventing the occurrence or enhancement of the severity of depression and anxiety in mice …

The delayed administration of dehydroepiandrosterone sulfate improves recovery of function after traumatic brain injury in rats

SW Hoffman, S Virmani, RM Simkins… - Journal of …, 2003 - liebertpub.com
The goal of the current study was to test the hypothesis that dehydroepiandrosterone-sulfate
(DHEAS), a pro-excitatory neurosteroid, could facilitate recovery of function in male rats after …

Dehydroepiandrosterone and its sulfate enhance memory retention in mice

JF Flood, GE Smith, E Roberts - Brain research, 1988 - Elsevier
Dehydroepiandrosterone (DHEA) and its sulfate (DHEAS), major naturally occuring
precursors of both androgenic and estrogenic steroids, were shown in the present study to …

[HTML][HTML] Actions of dehydroepiandrosterone and its sulfate in the central nervous system: effects on cognition and emotion in animals and humans

OT Wolf, C Kirschbaum - Brain Research Reviews, 1999 - Elsevier
Dehydroepiandrosterone (DHEA) and its sulfate ester, DHEAS, exert multiple effects in the
rodent central nervous system (CNS). Most of them seem to be mediated through their non …

Memory-enhancing effects of DHEAS in aged mice on a win-shift water escape task

M Markowski, M Ungeheuer, D Bitran, C Locurto - Physiology & behavior, 2001 - Elsevier
The steroid hormone, dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) have been
implicated in age-associated deficits in memory. Numerous studies have demonstrated the …