Adaptive interactions between HLA and HIV-1: highly divergent selection imposed by HLA class I molecules with common supertype motifs
M John, D Heckerman, I James, LP Park… - The Journal of …, 2010 - journals.aai.org
Abstract Currently, 1.1 million individuals in the United States are living with HIV-1 infection.
Although this is a relatively small proportion of the global pandemic, the remarkable mix of …
Although this is a relatively small proportion of the global pandemic, the remarkable mix of …
HLA heterozygote advantage against HIV-1 is driven by quantitative and qualitative differences in HLA allele-specific peptide presentation
Pathogen-mediated balancing selection is regarded as a key driver of host immunogenetic
diversity. A hallmark for balancing selection in humans is the heterozygote advantage at …
diversity. A hallmark for balancing selection in humans is the heterozygote advantage at …
HLA-B molecules target more conserved regions of the HIV-1 proteome
AIF Costa, X Rao, E LeChenadec, D van Baarle… - Aids, 2010 - journals.lww.com
Background: HLA-B alleles of HIV-infected individuals have been shown to have a major
impact on their rate of progression toward AIDS, and the T-cell responses they restrict are …
impact on their rate of progression toward AIDS, and the T-cell responses they restrict are …
HIV peptidome-wide association study reveals patient-specific epitope repertoires associated with HIV control
J Arora, PJ McLaren, N Chaturvedi… - Proceedings of the …, 2019 - National Acad Sciences
Genetic variation in the peptide-binding groove of the highly polymorphic HLA class I
molecules has repeatedly been associated with HIV-1 control and progression to AIDS …
molecules has repeatedly been associated with HIV-1 control and progression to AIDS …
Impact of HLA class I functional divergence on HIV control
M Viard, C O'hUigin, Y Yuki, AA Bashirova, DR Collins… - Science, 2024 - science.org
Heterozygosity of Human leukocyte antigen (HLA) class I genes is linked to beneficial
outcomes after HIV infection, presumably through greater breadth of HIV epitope …
outcomes after HIV infection, presumably through greater breadth of HIV epitope …
Grouping HLA-B locus serologie specificities according to shared structural motifs suggests that different peptide-anchoring pockets may have contrasting influences …
S Itescu, S Rose, E Dwyer, R Winchester - Human Immunology, 1995 - Elsevier
Two different groups of HLA-B specificities were associated with two contrasting outcomes of
HIV-1 infection. HLA-B45,-B49, and-B50 were each found at a moderately increased …
HIV-1 infection. HLA-B45,-B49, and-B50 were each found at a moderately increased …
Differential selection pressure exerted on HIV by CTL targeting identical epitopes but restricted by distinct HLA alleles from the same HLA supertype
HLA diversity is seen as a major challenge to CTL vaccines against HIV. One current
approach focuses on “promiscuous” epitopes, presented by multiple HLA alleles from within …
approach focuses on “promiscuous” epitopes, presented by multiple HLA alleles from within …
Correlates of protective cellular immunity revealed by analysis of population-level immune escape pathways in HIV-1
ABSTRACT HLA class I-associated polymorphisms identified at the population level mark
viral sites under immune pressure by individual HLA alleles. As such, analysis of their …
viral sites under immune pressure by individual HLA alleles. As such, analysis of their …
The major genetic determinants of HIV-1 control affect HLA class I peptide presentation
International HIV Controllers Study - Science, 2010 - science.org
Infectious and inflammatory diseases have repeatedly shown strong genetic associations
within the major histocompatibility complex (MHC); however, the basis for these associations …
within the major histocompatibility complex (MHC); however, the basis for these associations …
Advantage of rare HLA supertype in HIV disease progression
The highly polymorphic human leukocyte antigen (HLA) class I molecules help to determine
the specificity and repertoire of the immune response. The great diversity of these antigen …
the specificity and repertoire of the immune response. The great diversity of these antigen …