Systems immunology analysis reveals the contribution of pulmonary and extrapulmonary tissues to the immunopathogenesis of severe COVID-19 patients

SM Hammoudeh, AM Hammoudeh… - Frontiers in …, 2021 - frontiersin.org
As one of the current global health conundrums, COVID-19 pandemic caused a dramatic
increase of cases exceeding 79 million and 1.7 million deaths worldwide. Severe …

Documenting the immune response in patients with COVID-19-induced acute respiratory distress syndrome

J Lu, X Zeng, W Lu, J Feng, Y Yang, Y Wei… - Frontiers in Cell and …, 2023 - frontiersin.org
Introduction: Coronavirus disease 2019 (COVID-19) can lead to acute respiratory distress
syndrome (ARDS) and life-threatening multi-organ failure with increased levels of …

SARS-CoV-2 activates lung epithelial cell proinflammatory signaling and leads to immune dysregulation in COVID-19 patients

H Chen, W Liu, Y Wang, D Liu, L Zhao, J Yu - EBioMedicine, 2021 - thelancet.com
Abstract Background The outbreak of Coronavirus disease 2019 (COVID-19) caused by
SARS-CoV-2 infection has become a global health emergency. We aim to decipher SARS …

Compartmentalized Regulation of Pulmonary and Systemic Inflammation in Critical COVID-19 Patients

L Santiago, MH Gonçalves-Pereira, MS Vieira… - Viruses, 2023 - mdpi.com
Critical COVID-19 has been associated with altered patterns of cytokines. Distinct
inflammatory processes in systemic and pulmonary sites have been reported, but studies …

Predictive monitoring and therapeutic immune biomarkers in the management of clinical complications of COVID-19

H Fouladseresht, M Doroudchi, N Rokhtabnak… - Cytokine & growth factor …, 2021 - Elsevier
Abstract The coronavirus disease-2019 (COVID-19), caused by severe acute respiratory
syndrome coronavirus-2 (SARS-CoV-2), appears with a wide spectrum of mild-to-critical …

Inflammation and antiviral immune response associated with severe progression of COVID-19

Q Zhang, Y Meng, K Wang, X Zhang, W Chen… - Frontiers in …, 2021 - frontiersin.org
Coronavirus disease-2019 (COVID-19) is a novel respiratory disease induced by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). It remains poorly understood how …

Establishing a unified COVID-19 “immunome”: integrating coronavirus pathogenesis and host immunopathology

E Wauters, K Thevissen, C Wouters… - Frontiers in …, 2020 - frontiersin.org
Coronavirus disease-2019 (COVID-19), caused by severe acute respiratory syndrome
coronavirus-2 (SARS-CoV-2), has created an unprecedented global health crisis. Because …

Cross-talk between the airway epithelium and activated immune cells defines severity in COVID-19

RL Chua, S Lukassen, S Trump, BP Hennig… - MedRxiv, 2020 - medrxiv.org
The clinical course of COVID-19 is highly variable, however, underlying host factors and
determinants of severe disease are still unknown. Based on single-cell transcriptomes of …

[HTML][HTML] Longitudinal profiling of respiratory and systemic immune responses reveals myeloid cell-driven lung inflammation in severe COVID-19

PA Szabo, P Dogra, JI Gray, SB Wells, TJ Connors… - Immunity, 2021 - cell.com
Immune response dynamics in coronavirus disease 2019 (COVID-19) and their severe
manifestations have largely been studied in circulation. Here, we examined the relationship …

Characterisation of the pro-inflammatory cytokine signature in severe COVID-19

HC Hawerkamp, AH Dyer, ND Patil… - Frontiers in …, 2023 - frontiersin.org
Clinical outcomes from infection with SARS-CoV-2, the cause of the COVID-19 pandemic,
are remarkably variable ranging from asymptomatic infection to severe pneumonia and …