Evaluation of protective effect of multi-epitope DNA vaccine encoding six antigen segments of Toxoplasma gondii in mice

S Liu, L Shi, Y Cheng, G Fan, H Ren, Y Yuan - Parasitology research, 2009 - Springer
To investigate the vaccine potential of multi-epitope vaccines against toxoplasmosis, a multi-
epitope DNA vaccine, eukaryotic plasmid pcDNA3. 1/T-ME expressing six antigen segments …

Evaluation of protective effect of multiantigenic DNA vaccine encoding MIC3 and ROP18 antigen segments of Toxoplasma gondii in mice

D Qu, J Han, A Du - Parasitology research, 2013 - Springer
The high incidence and severe damage caused by Toxoplasma gondii infection clearly
indicates the need for the development of a vaccine. In this study, we evaluated the immune …

Long-Term Protective Immune Response Elicited by Vaccination with an Expression Genomic Library of Toxoplasma gondii

A Fachado, A Rodriguez, J Molina… - Infection and …, 2003 - Am Soc Microbiol
Immunization of BALB/c mice with an expression genomic library of Toxoplasma gondii
induces a Th1-type immune response, with recognition of several T. gondii proteins (21 to …

Multicomponent DNA vaccine-encoding Toxoplasma gondii GRA1 and SAG1 primes: anti-Toxoplasma immune response in mice

XN Wu, J Lin, X Lin, J Chen, ZL Chen, JY Lin - Parasitology research, 2012 - Springer
A multicomponent DNA vaccine, encoding Toxoplasma gondii GRA1 and SAG1, was
constructed and tested for its ability to confer protection. BALB/c mice were challenged with …

Toxoplasma gondii: vaccination with a DNA vaccine encoding T-and B-cell epitopes of SAG1, GRA2, GRA7 and ROP16 elicits protection against acute toxoplasmosis …

A Cao, Y Liu, J Wang, X Li, S Wang, Q Zhao, H Cong… - Vaccine, 2015 - Elsevier
Toxoplasma gondii (T. gondii) is an obligate, intracellular, protozoan parasite that infects
large variety of warm-blooded animals including humans, livestock, and marine mammals …

Evaluation of Anti-Toxoplasma gondii Immune Responses in BALB/c Mice Induced by DNA Vaccines Encoding Surface Antigen 1 (SAG1) and 3 (SAG3)

H Sobati, A Dalimi, B Kazemi, F Ghaffarifar - … Genetics, Microbiology and …, 2019 - Springer
DNA vaccine cocktail construction is one of the most important strategies for the
development of new generation multiantigenic vaccine against toxoplasmosis. In the present …

Evaluation of the immune response induced by multiantigenic DNA vaccine encoding SAG1 and ROP2 of Toxoplasma gondii and the adjuvant properties of murine …

J Zhang, S He, H Jiang, T Yang, H Cong, H Zhou… - Parasitology …, 2007 - Springer
The heavy incidence and severe or lethal damages of toxoplasmosis clearly indicate the
need for the development of a more effective vaccine. In the present study, we constructed a …

Evaluation of protective immunity induced by DNA vaccination with genes encoding Toxoplasma gondii GRA17 and GRA23 against acute toxoplasmosis in mice

WN Zhu, JL Wang, K Chen, DM Yue, XX Zhang… - Experimental …, 2017 - Elsevier
Toxoplasma gondii, an obligatory intracellular protozoan, can cause serious public health
problems and economic losses worldwide. Two novel dense granule proteins (GRA17 and …

Toxoplasma gondii: Protective immunity induced by a DNA vaccine expressing GRA1 and MIC3 against toxoplasmosis in BALB/c mice

P Gong, L Cao, Y Guo, H Dong, S Yuan, X Yao… - Experimental …, 2016 - Elsevier
The intracellular parasite Toxoplasma gondii is a major cause of abortion and neonatal loss
in livestock, and can cause severe illness to human with weakened immune system. The …

Protective Effect of Vaccination with Toxoplasma Lysate Antigen and CpG as an Adjuvant against Toxoplasma gondii in Susceptible C57BL/6 Mice

M El‐Malky, L Shaohong, T Kumagai… - Microbiology and …, 2005 - Wiley Online Library
Infection with the intracellular protozoan parasite Toxoplasma gondii causes serious public
health problems to both humans and livestock and of great economic impact worldwide …