Transcriptomic profiling of Aspergillus flavus in response to 5-azacytidine

JQ Lin, XX Zhao, QQ Zhi, M Zhao, ZM He - Fungal Genetics and Biology, 2013 - Elsevier
Aspergillus flavus is a common saprophyte and opportunistic pathogen producing aflatoxin
(AF) and many other secondary metabolites. 5-Azacytidine (5-AC), a derivative of the …

Deep sequencing analysis of transcriptomes in Aspergillus flavus in response to resveratrol

H Wang, Y Lei, L Yan, K Cheng, X Dai, L Wan, W Guo… - BMC microbiology, 2015 - Springer
Background Resveratrol has been reported as a natural phytoalexin that inhibits infection or
the growth of certain fungi including Aspergillus flavus. Our previous research revealed that …

New insights of transcriptional regulator AflR in Aspergillus flavus physiology

P Wang, J Xu, PK Chang, Z Liu, Q Kong - Microbiology Spectrum, 2022 - Am Soc Microbiol
Aspergillus flavus aflR, a gene encoding a Zn (II) 2Cys6 DNA-binding domain, is an
important transcriptional regulator of the aflatoxin biosynthesis gene cluster. Our previous …

Large-Scale Comparative Analysis of Eugenol-Induced/Repressed Genes Expression in Aspergillus flavus Using RNA-seq

C Lv, P Wang, L Ma, M Zheng, Y Liu… - Frontiers in microbiology, 2018 - frontiersin.org
Aflatoxin B1 (AFB1), which is mainly produced by Aspergillus flavus and Aspergillus
parasiticus, is the most toxic and hepatocarcinogenic polyketide known. Chemical …

Transcriptome Analysis of Aspergillus flavus Reveals veA-Dependent Regulation of Secondary Metabolite Gene Clusters, Including the Novel Aflavarin Cluster

JW Cary, Z Han, Y Yin, JM Lohmar, S Shantappa… - Eukaryotic …, 2015 - Am Soc Microbiol
The global regulatory veA gene governs development and secondary metabolism in
numerous fungal species, including Aspergillus flavus. This is especially relevant since A …

Repressor-AFLR interaction modulates aflatoxin biosynthesis in Aspergillus parasiticus

PK Chang, J Yu, D Bhatnagar, TE Cleveland - Mycopathologia, 1999 - Springer
Regulation of aflatoxin (AF) biosynthesis likely involves a complex interplay of positive-and
negative-acting factors that are affected by physiological cues responsive to internal and …

Unraveling the gene regulatory networks of the global regulators VeA and LaeA in Aspergillus nidulans

H Moon, MK Lee, I Bok, JW Bok, NP Keller… - Microbiology …, 2023 - Am Soc Microbiol
In the filamentous fungus Aspergillus nidulans, the velvet family protein VeA and the global
regulator of secondary metabolism LaeA govern development and secondary metabolism …

Comprehensive analysis of aflatoxin B1 biosynthesis in Aspergillus flavus via transcriptome-wide m6A methylome response to cycloleucine

L Liang, X Wang, H Lan, S Wei, Y Lei, S Zhang… - Journal of Hazardous …, 2024 - Elsevier
Aspergillus flavus and its toxic aflatoxins secondary metabolites contaminate food and
grains, posing a severe threat to human health and leading to liver cancer. Here, we …

5-Azacytidine inhibits aflatoxin biosynthesis in Aspergillus flavus

JQ Lin, XX Zhao, CC Wang, Y Xie, GH Li, ZM He - Annals of Microbiology, 2013 - Springer
Aflatoxins, mainly produced by Aspergillus flavus and A. parasiticus, are a group of potent
mycotoxins with carcinogenic, hepatotoxic, and immunosuppressive properties. Many …

Transcriptional Stages of Conidia Germination and Associated Genes in Aspergillus flavus: An Essential Role for Redox Genes

C Li, S Jia, SA Rajput, D Qi, S Wang - Toxins, 2022 - mdpi.com
Aflatoxin is a threatening mycotoxin primarily present in the agricultural environment,
especially in food and feedstuff, and poses significant global health risks. Aflatoxins are …