Joint inflammation is present in the majority of OA patients and pro-inflammatory mediators,
such as IL-6, are actively involved in disease progression. Increased levels of IL-6 in serum …

Osteoarthritis (OA) is associated with cartilage destruction, subchondral bone remodeling
and inflammation of the synovial membrane, although the etiology and pathogenesis …

Interleukin-6 (IL-6) is a cytokine that can facilitate autoimmune phenomena, amplify acute
inflammation and promote the evolution into a chronic inflammatory state. In addition, it is a …

The concept of interleukin-1 (IL-1) as a target in osteoarthritis (OA) has been an attractive
one for many years. It is a highly potent inducer of cartilage degradation, causing the …

Interleukin (IL)-10 is a well known anti-inflammatory and immunoregulatory cytokine, mainly
released by, and acting on cells of the immune system such as monocytes, macrophages, T …

Osteoarthritis (OA) is a major disabling disease and is ranked as a major cause of chronic
pain in adults. The pathology of the illness is characterized by a loss of articular cartilage …

There is increasing evidence that the IL-6 family of cytokines and signaling pathways
downstream of the common gp130 receptor subunit are important in joint development, in …

Osteoarthritis (OA) can be regarded as a chronic, painful and degenerative disease that
affects all tissues of a joint and one of the major endpoints being loss of articular cartilage. In …

OBJECTIVE: Diminish interleukin-1β (IL-1β) signaling in a model of primary osteoarthritis by
RNA interference-based transcript reduction or receptor blockade, and quantify changes …

Rheumatoid arthritis (RA) is a chronic, debilitating autoimmune disorder involving
inflammation and progressive destruction of the joints, affecting up to 1% of the population …