The cytokine storm and COVID‐19

B Hu, S Huang, L Yin - Journal of medical virology, 2021 - Wiley Online Library
Abstract Coronavirus disease 2019 (COVID‐19), which began in Wuhan, China, in
December 2019, has caused a large global pandemic and poses a serious threat to public …

Immune response in COVID-19: addressing a pharmacological challenge by targeting pathways triggered by SARS-CoV-2

M Catanzaro, F Fagiani, M Racchi, E Corsini… - Signal transduction and …, 2020 - nature.com
To date, no vaccines or effective drugs have been approved to prevent or treat COVID-19
and the current standard care relies on supportive treatments. Therefore, based on the fast …

[HTML][HTML] Recent insight into SARS-CoV2 immunopathology and rationale for potential treatment and preventive strategies in COVID-19

S Lega, S Naviglio, S Volpi, A Tommasini - Vaccines, 2020 - mdpi.com
As the outbreak of the new coronavirus (SARS-CoV-2) infection is spreading globally, great
effort is being made to understand the disease pathogenesis and host factors that …

COVID-19: in the eye of the cytokine storm

R De la Rica, M Borges, M Gonzalez-Freire - Frontiers in immunology, 2020 - frontiersin.org
The dysregulated release of cytokines has been identified as one of the key factors behind
poorer outcomes in COVID-19. This “cytokine storm” produces an excessive inflammatory …

Tackling the cytokine storm in COVID-19, challenges and hopes

SM Abdin, SM Elgendy, SK Alyammahi, DW Alhamad… - Life Sciences, 2020 - Elsevier
The outbreak of Coronavirus disease 2019 (COVID-19) is the current world health concern,
presenting a public health dilemma with ascending morbidity and mortality rates exceeding …

Monocytes and macrophages, targets of severe acute respiratory syndrome coronavirus 2: the clue for coronavirus disease 2019 immunoparalysis

A Boumaza, L Gay, S Mezouar, E Bestion… - The Journal of …, 2021 - academic.oup.com
Abstract Background Coronavirus disease 2019 (COVID-19) clinical expression is
pleiomorphic, severity is related to age and comorbidities such as diabetes and …

Dysregulation of the immune response in coronavirus disease 2019

L Mohamed Khosroshahi, N Rezaei - Cell Biology International, 2021 - Wiley Online Library
Severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) can trigger a cytokine
storm in the pulmonary tissue by releasing various types of mediators, leading to acute …

Pathogenic T-cells and inflammatory monocytes incite inflammatory storms in severe COVID-19 patients

Y Zhou, B Fu, X Zheng, D Wang, C Zhao… - National Science …, 2020 - academic.oup.com
Pathogenic human coronavirus infections, such as severe acute respiratory syndrome CoV
(SARS-CoV) and Middle East respiratory syndrome CoV (MERS-CoV), cause high morbidity …

Role of IFN and complements system: innate immunity in SARS-CoV-2

T Shibabaw, MD Molla, B Teferi… - Journal of inflammation …, 2020 - Taylor & Francis
The critical role of the innate immune system has been confirmed in driving local and
systemic inflammation and the cytokine release storm in severe acute respiratory syndrome …

COVID-19: immunology, immunopathogenesis and potential therapies

A Bhardwaj, L Sapra, C Saini, Z Azam… - International reviews …, 2022 - Taylor & Francis
Abstract The Coronavirus Disease-2019 (COVID-19) imposed public health emergency and
affected millions of people around the globe. As of January 2021, 100 million confirmed …