Extracellular acidification occurs in inflamed tissue and the tumor microenvironment;
however, a systematic study on how pH sensing contributes to tissue homeostasis is lacking …

Abstract Background and Aims During active inflammation, intraluminal intestinal pH is
decreased in patients with inflammatory bowel disease [IBD]. Acidic pH may play a role in …

At mucosal sites such as the intestine, the immune system launches robust immunity against
invading pathogens while maintaining a state of tolerance to commensal flora and ingested …

GPR4 is a proton-sensing G protein-coupled receptor that can be activated by extracellular
acidosis. It has recently been demonstrated that activation of GPR4 by acidosis increases …

Diet and gut microbial metabolites mediate host immune responses and are central to the
maintenance of intestinal health. The metabolite-sensing G-protein coupled receptors …

Single-nucleotide polymorphisms in the gene encoding G protein-coupled receptor 35
(GPR35) are associated with increased risk of inflammatory bowel disease. However, the …

Background A novel family of proton-sensing G protein-coupled receptors, including OGR1,
GPR4, and TDAG8, was identified to be important for physiological pH homeostasis and …

Although numerous polymorphisms have been associated with inflammatory bowel disease
(IBD), identifying the function of these genetic factors has proved challenging. Here we …

Metabolic changes associated with tissue inflammation result in significant extracellular
acidosis (EA). Within mucosal tissues, intestinal epithelial cells (IEC) have evolved adaptive …

Abstract Background and Aims Group 3 innate lymphoid cells [ILC3s] sense environmental
signals and are critical in gut homeostasis and immune defence. G-protein-coupled …